Advertisement

Novel dental nanocomposites: fabrication and investigation of their physicochemical, mechanical and biological properties

  • Mehdi Jaymand
  • Mehrdad Lotfi
  • Jaleh Barar
  • Morteza Eskandani
  • Hadi Maleki
Article
  • 46 Downloads

Abstract

The aim of this study was to investigate biological, physicochemical and mechanical characteristics of a series of novel dental restorative nanocomposites that comprise dendritic methacrylate end-caped monomers, triethylene glycol dimethacrylate (TEGDMA; as diluting monomer) and modified silica nanoparticles (\(\hbox {M-SiO}_{2}\); as inorganic filler). The cytotoxicity effects of the monomers and fabricated nanocomposites were examined against NIH3T3 cells (the standard fibroblast cell line) through MTT and trypan blue cell viability tests, respectively. The antibacterial activities of the monomers were evaluated against Lactobacillus plantarum by standard agar disk diffusion approach. The mechanical properties (flexural strength (FS) and compressive strength (CS)) as well as some physicochemical characteristics such as water sorption (WS), sol fraction (SF) and double bond conversion (DC) were also investigated, and compared with corresponding characteristics of 3M Filtek Z250 as a reference. Thus, the fabricated nanocomposites have potential as dental restorative materials mainly due to their suitable biological, physicochemical and mechanical properties.

Keywords

Dendritic methacrylate dental restorative materials biological aspects mechanical properties physicochemical characteristics 

Notes

Acknowledgements

We wish to express our gratitude to the Research Center for Pharmaceutical Nanotechnology (RCPN), Tabriz University of Medical Sciences, for financial support for this project (Grant Number: 93002, which was a part of PhD thesis Number: 93/002/131/4).

References

  1. 1.
    Jaymand M, Lotfi M and Lotfi R 2016 RSC Adv.  6 43127CrossRefGoogle Scholar
  2. 2.
    Milia E, Cumbo E, Cardoso R J A and Gallina G 2012 Curr. Pharm. Des.  18 5542CrossRefGoogle Scholar
  3. 3.
    Huyang G, Debertin A E and Sun J 2016 Mater. Des.  94 295CrossRefGoogle Scholar
  4. 4.
    Zhang L, Gao Y, Chen Q, Tian M and Fong H 2010 J. Mater. Sci.  45 2521CrossRefGoogle Scholar
  5. 5.
    Viljanen E K, Skrifvars M and Vallittu P K 2007 Dent. Mater.  23 1420CrossRefGoogle Scholar
  6. 6.
    Viljanen E K, Langer S, Skrifvars M and Vallittu P K 2006 Dent. Mater.  22 845CrossRefGoogle Scholar
  7. 7.
    Wang Z, Shen Y and Haapasalo M 2014 Dent. Mater.  30 e1CrossRefGoogle Scholar
  8. 8.
    Featherstone J D and Doméjean S 2012 Adv. Dent. Res.  24 28CrossRefGoogle Scholar
  9. 9.
    Flausino J S, Soares P B F, Carvalho V F, Magalhães D, Da Silva W M, Costa H L et al 2014 J. Mater. Sci.  49 6820CrossRefGoogle Scholar
  10. 10.
    Dionysopoulos D, Eugenia K, Maria H and Nikolaos K 2013 Dent. Mater. J.  32 296CrossRefGoogle Scholar
  11. 11.
    Xu X, Wang Y, Liao S, Wen Z T and Fan Y 2012 J. Biomed. Mater. Res. Part B  100 1151CrossRefGoogle Scholar
  12. 12.
    Burke F M, Ray N J and McConnell R J 2006 Int. Dent. J.  56 33CrossRefGoogle Scholar
  13. 13.
    Cheng L, Weir M D, Zhang K, Arola D D, Zhou X and Xu H H K 2013 J. Dent.  41 345CrossRefGoogle Scholar
  14. 14.
    DePaola P F, Soparkar P, Foley S, Bookstein F and Bakhos Y 1977 Community Dent. Oral Epid.  5 7CrossRefGoogle Scholar
  15. 15.
    Ferracane J L 2011 Dent. Mater.  27 29CrossRefGoogle Scholar
  16. 16.
    Kaisarly D and Gezawi M E 2016 Odontology  104 257CrossRefGoogle Scholar
  17. 17.
    Van Landuyt K L, Nawrot T, Geebelen B, De Munck J, Snauwaert J, Yoshihara K et al 2011 Dent. Mater.  27 723CrossRefGoogle Scholar
  18. 18.
    Jaymand M, Lotfi M, Barar J and Kimyai S 2017 Res. Chem. Intermed.  43 5707CrossRefGoogle Scholar
  19. 19.
    Goncalves L, Filho J D N, Guimaraes J A, Poskus L T and Silva E M 2008 J. Biomed. Mater. Res. B  85 320CrossRefGoogle Scholar
  20. 20.
    Liang X, Huang Q, Liu F, He J and Lin Z 2013 J. Appl. Polym. Sci.  129 3373CrossRefGoogle Scholar
  21. 21.
    Hatamzadeh M, Najafi-Moghadam P, Baradar-Khoshfetrat A, Jaymand M and Massoumi B 2016 Polymer  107 177CrossRefGoogle Scholar
  22. 22.
    Jaymand M, Sarvari R, Abbaszadeh P, Massoumi B, Eskandani M and Beygi-Khosrowshahi Y 2016 J. Biomed. Mater. Res. A  104 2673CrossRefGoogle Scholar
  23. 23.
    Miller L, Leor J and Rubinsky B 2005 Technol. Cancer Res. Treat.  4 699CrossRefGoogle Scholar
  24. 24.
    Wang L, D’Alpino P H P, Lopes L G and Pereira J C 2003 J. Appl. Oral Sci.  11 162CrossRefGoogle Scholar
  25. 25.
    Rodríguez H A, Giraldo L F and Casanova H 2015 Dent. Mater.  31 789CrossRefGoogle Scholar
  26. 26.
    Rupf S, Balkenhol M, Sahrhage T O, Baum A, Chromik J N, Ruppert K et al 2012 Dent. Mater.  28 974CrossRefGoogle Scholar
  27. 27.
    Emmler J, Seiss M, Kreppel H, Reichl F X, Hickel R and Kehe K 2008 Dent. Mater.  24 1670CrossRefGoogle Scholar
  28. 28.
    Lohbauer U, Belli R and Ferracane J L 2013 J. Dent. Res.  92 584CrossRefGoogle Scholar

Copyright information

© Indian Academy of Sciences 2018

Authors and Affiliations

  • Mehdi Jaymand
    • 1
  • Mehrdad Lotfi
    • 1
    • 2
  • Jaleh Barar
    • 1
    • 3
  • Morteza Eskandani
    • 1
  • Hadi Maleki
    • 1
  1. 1.Research Center for Pharmaceutical NanotechnologyTabriz University of Medical SciencesTabrizIran
  2. 2.Department of Endodontics, Dental FacultyTabriz University of Medical SciencesTabrizIran
  3. 3.Department of Pharmaceutics, Faculty of PharmacyTabriz University of Medical SciencesTabrizIran

Personalised recommendations