Advanced nanofibrous textile-based dressing material for treating chronic wounds

  • Isabel Herrmann
  • Eko Supriyanto
  • Saravana Kumar JaganathanEmail author
  • A Manikandan


In the present work, an electrospun nanofibrous textile composed of polyurethane (PU), sodium bicarbonate (\(\hbox {NaHCO}_{3}\)) and pantothenic acid (PA) is developed for treating chronic wounds. Wounds are a common health problem and in particular, the chronic wounds such as vascular ulcers, diabetic ulcers and pressure ulcers cause a large number of morbidity and mortality. The main problems of the chronic wounds are prolonged inflammation phase and presence of acidic environment. These events deactivate the operation of growth factors and also the progression of natural healing mechanism. Hence, various types of advanced textile-based dressings are developed to address the clinical complications associated with chronic wound management. The prepared electrospun scaffolds were characterized to study their physicochemical and haemocompatible properties. The scanning electron microscopy micrographs depicted continuous, smooth-interconnected nanofibrous morphology of PU–NaHCO\(_{3}\)–PA scaffolds. The Fourier transform infrared spectroscopy spectra indicated the addition of NaHCO\(_{3}\) and PA-based hydrophilic chemical groups, which significantly enhanced the wettability of the composites. Further, the PU–NaHCO\(_{3}\)–PA composite membrane inferred to have a highly porous structure with the mean porosity of 79.4 ± 4.8%, which may provide a conducive environment for adherence and proliferation of skin cells. The composite scaffold also offers a highly haemocompatible surface by delaying coagulation of blood through contact activation pathways and by limiting red blood cells damage. Therefore, the excellent physicochemical properties, blood compatibility and the delivery of PA are anticipated to speed up the impaired healing process of chronic wounds.


Advanced textiles chronic wound healing electrospinning sodium bicarbonate pantothenic acid 



This work was partially supported by a research university Grant, Vot Numbers Q.J130000.2545.12H80 and Q.J130000.2545.14H59.


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Copyright information

© Indian Academy of Sciences 2018

Authors and Affiliations

  • Isabel Herrmann
    • 1
    • 2
  • Eko Supriyanto
    • 1
  • Saravana Kumar Jaganathan
    • 3
    • 4
    • 5
    Email author
  • A Manikandan
    • 6
  1. 1.Faculty of Biosciences and Medical EngineeringUniversiti Teknologi MalaysiaSkudaiMalaysia
  2. 2.Ilmenau Institute of Biomedical Engineering and Computer ScienceTechnical University of IlmenauIlmenauGermany
  3. 3.Department for Management of Science and Technology DevelopmentTon Duc Thang UniversityHo Chi Minh CityVietnam
  4. 4.Faculty of Applied SciencesTon Duc Thang UniversityHo Chi Minh CityVietnam
  5. 5.IJNUTM Cardiovascular Engineering Centre, Department of Clinical Sciences, Faculty of Biosciences and Medical EngineeringUniversiti Teknologi MalaysiaSkudaiMalaysia
  6. 6.Department of ChemistryBharath Institute of Higher Education and Research, Bharath UniversityChennaiIndia

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