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Instrumental characterization of the smectite clay–gentamicin hybrids

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Abstract

This paper focusses on the intercalation of clay mineral with gentamicin (an aminoglycoside antibiotic). The smectite clay–gentamicin hybrids were prepared by a solution intercalation at 60∘C and the process was carried out on unmodified smectite clay and on smectite after Na+ ionic activation. The resulting structural/microstructural properties and the potential for introducing gentamicin between smectite clay layers were investigated by means of X-ray diffraction, Fourier transform infrared spectroscopic techniques and transmission electron microscopy and scanning electron microscopy with energy-dispersive spectroscopy X-ray analysis. The results confirm the successful intercalation of gentamicin into the interlayer space of smectite clay, demonstrating that the material thus obtained could potentially be used as a drug carrier.

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Acknowledgements

Work was carried out within the framework of funding for statutory activities of AGH University of Science and Technology in Cracow, Faculty of Materials Science and Ceramics (11.11.160.617).

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Authors and Affiliations

  1. AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Cracow, 30-059, Poland

    ALICJA RAPACZ-KMITA, EWA STODOLAK-ZYCH, MAGDALENA ZIABKA & AGNIESZKA ROZYCKA

  2. AGH University of Science and Technology, Faculty of Energy and Fuels, Cracow, 30-059, Poland

    MAGDALENA DUDEK

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  1. ALICJA RAPACZ-KMITA
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RAPACZ-KMITA, A., STODOLAK-ZYCH, E., ZIABKA, M. et al. Instrumental characterization of the smectite clay–gentamicin hybrids. Bull Mater Sci 38, 1069–1078 (2015). https://doi.org/10.1007/s12034-015-0943-7

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