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Studies on in vitro release of CPM from semi-interpenetrating polymer network (IPN) composed of chitosan and glutamic acid

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Abstract

Interpenetrating polymer network (IPN) beads consisting of chitosan-glutamic acid were prepared for in vitro study of controlled release of chlorpheniramine maleate (CPM). A viscous solution of chitosan-glutamic acid was prepared in 2% acetic acid solution, extruded as droplets through a syringe to alkalimethanol solution and the precipitated beads were crosslinked using glutaraldehyde solution. Swelling and drug release studies were carried out. Transport of release medium through the semi-IPN depended upon its pH and extent of crosslinking. The structural and morphological studies of beads were carried out by using a scanning electron microscope (SEM). The larger surface area of beads as well as their ease of handling makes them ideal agents of controlled release.

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Authors and Affiliations

  1. Department of Chemical Technology, Sant Longowal Institute of Engineering and Technology, Longowal, 148 106, India

    K. Kumari & P. P. Kundu

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  1. K. Kumari
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  2. P. P. Kundu
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Correspondence to P. P. Kundu.

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Kumari, K., Kundu, P.P. Studies on in vitro release of CPM from semi-interpenetrating polymer network (IPN) composed of chitosan and glutamic acid. Bull Mater Sci 31, 159–167 (2008). https://doi.org/10.1007/s12034-008-0028-y

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  • DOI: https://doi.org/10.1007/s12034-008-0028-y

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