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Recent Advances in the Role of Different Nanoparticles in the Various Biosensors for the Detection of the Chikungunya Virus

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Abstract

Humans contract the Chikungunya virus (CHIKV), an alphavirus transmitted by mosquitoes that induces acute and chronic musculoskeletal discomfort and fever. Millions of cases of the disease have been attributed to CHIKV in the Indian Ocean region since 2004, and the virus has since spread to Europe, the Middle East, and the Pacific. The exponential proliferation of CHIKV in recent times underscores the critical nature of implementing preventative measures and exploring potential control strategies. The principal laboratory test employed to diagnose infection in serum samples collected over six days after the onset of symptoms is the detection of CHIKV or viral RNA. Although two commercially available real-time reverse transcription–polymerase chain reaction products exist, data on their validity are limited. A diagnostic instrument that is rapid, sensitive, specific, and cost-effective is, therefore an absolute necessity, particularly in developing nations. Biosensors have demonstrated considerable potential in the realm of pathogen detection. The rapid and sensitive detection of viruses has been facilitated by the development of numerous types of biosensors, including affinity-based nano-biosensors, graphene affinity-based biosensors, optical nano-biosensors, surface Plasmon Resonance-based optical nano-biosensors, and electrochemical nano-biosensors. Furthermore, the utilization of nanomaterials for signal extension, including but not limited to gold and silver nanoparticles, quantum dots, and iron oxide NPs, has enhanced the precision and sensitivity of biosensors. The developed innovative diagnostic method is time-efficient, precise, and economical; it can be implemented as a point-of-care device. The technique may be implemented in diagnostic laboratories and hospitals to identify patients infected with CHIKV. Throughout this article, we have examined a multitude of CHIKV nano-biosensors and their respective properties. Following a discussion of representative nanotechnologies for biosensors, numerous NPs-assisted CHIKV nano-biosensors are summarized in this article. As a result, we anticipate that this review will furnish a significant foundation for advancing innovative CHIKV nano-biosensors.

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Acknowledgements

Thanks to all the scientists of the world who advance science and cure pain with their efforts.

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Authors and Affiliations

  1. Department of Pharmaceutical Engineering, University of Tehran, Tehran, Iran

    Seyed Abbas Shahrtash

  2. Department of Pharmacy, Al-Noor University College, Nineveh, Iraq

    Zahraa Sabah Ghnim

  3. Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran

    Mohammad Ghaheri

  4. Chemical Engineering Department, Amirkabir University of Technology, Tehran, Iran

    Javid Adabi

  5. Department of Microbiology, Zabol University of Medical Sciences, Zabol, Iran

    Mohammad amir Hassanzadeh

  6. Young Researchers and Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran

    Saman Yasamineh & Omid Gholizadeh

  7. Department of Medical Microbiology, Faculty of Medicine, Shahed University of Medical Science, Tehran, Iran

    Hamed Afkhami

  8. Department of Tissue Engineering and Applied Cell Science, School of Medicine, Qom University of Medical Sciences, Qom, Iran

    Amir Hossein Kheirkhah

  9. Azad Researcher, Virology and Biotechnology, Tehran, Iran

    Omid Gholizadeh

  10. Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran

    Hesam Zendehdel Moghadam

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OG, SY, HA, and AK wrote the main manuscript text and SY and prepared the figures. SASH, ZS, MG, JA, MH, reviewed and editing and OG, and HZ corresponding authors.

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Shahrtash, S.A., Ghnim, Z.S., Ghaheri, M. et al. Recent Advances in the Role of Different Nanoparticles in the Various Biosensors for the Detection of the Chikungunya Virus. Mol Biotechnol (2024). https://doi.org/10.1007/s12033-024-01052-6

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