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Long Non-coding RNA LINC01224 Promotes the Malignant Behaviors of Triple Negative Breast Cancer Cells via Regulating the miR-193a-5p/NUP210 Axis

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Abstract

Triple negative breast cancer (TNBC) is a prevalent malignant tumor in women and is characterized by high incidence and mortality. Current evidence has suggested that multiple long noncoding RNAs (lncRNAs) play regulatory roles in TNBC, while the specific mechanism of LINC01224 in TNBC remains unclear. In this study, LINC01224 was highly expressed in TNBC cells. Moreover, LINC01224 downregulation inhibited TNBC cell proliferation, migration, and invasion, and promoted cell apoptosis. Additionally, LINC01224 stabilized NUP210 mRNA through interaction with miR-193a-5p, thereby aggravating the malignant phenotypes of TNBC. Overall, LINC01224 functions as a tumor promoter for TNBC.

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Funding

The work was supported by Jiangsu Taizhou People's Hospital 2019 Hospital-level Scientific Research Fund Project (No. ZL201917).

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Authors and Affiliations

  1. Department of Breast Surgery, Jiangsu Taizhou People’s Hospital, Taizhou, 225300, Jiangsu, China

    Kai Sang, Tongbo Yi, Chi Pan & Jian Zhou

  2. Department of Oncology, Jiangsu Taizhou People’s Hospital, No.399 Hailing Road, Taizhou, 225300, Jiangsu, China

    Lei Yu

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Sang, K., Yi, T., Pan, C. et al. Long Non-coding RNA LINC01224 Promotes the Malignant Behaviors of Triple Negative Breast Cancer Cells via Regulating the miR-193a-5p/NUP210 Axis. Mol Biotechnol 65, 624–636 (2023). https://doi.org/10.1007/s12033-022-00555-4

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