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RHAU Peptides Specific for Parallel G-Quadruplexes: Potential Applications in Chemical Biology

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Abstract

G-quadruplexes (G4s) are non-canonical nucleic acid structures formed by guanine (G)-rich sequences, which are ubiquitously found in the human genome and transcriptome. Targeting G4s by specific ligands provides a powerful tool to monitor and regulate G4s-associated biological processes. RHAU peptides, derived from the G4-binding motif of “RNA Helicase associated with AU-rich element” (RHAU), have emerged as extraordinary ligands for specific recognition of parallel G4s. This review highlights the significances of recent studies investigating potential applications of the engineered RHAU peptides incorporated to different functional moieties.

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Acknowledgements

We would like to thank Prof. Anh Tuân Phan (Nanyang Technological University, Singapore) for scientific discussion.

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  1. Faculty of Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh City, Vietnam

    Le Tuan Anh Nguyen & Dung Thanh Dang

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Nguyen, L.T.A., Dang, D.T. RHAU Peptides Specific for Parallel G-Quadruplexes: Potential Applications in Chemical Biology. Mol Biotechnol 65, 291–299 (2023). https://doi.org/10.1007/s12033-022-00552-7

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