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Impact of Lysosomal Fraction on Melanin Synthesis Inhibition in a Zebrafish Melanogenesis Phenotype Model

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Abstract

To develop whitening cosmetic materials, we conducted a study on lysosomes that decisively contribute to the decomposition of melanin during autophagy in keratinocytes. In this study, we found that the lysosomal fraction inhibits melanin synthesis in melanocyte, and the potential for the whitening function of lysosomal fraction to degrade melanin in the cells, or accompany other melanin synthesis inhibition pathways, including tyrosinase inhibition. Additionally, through the zebrafish test, we confirmed the effect of lysosomal fraction on melanin production in vivo. The results suggest that the lysosome fraction effectively reduces melanin or inhibits melanogenesis in a melanogenesis phenotype whole-animal model.

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Acknowledgements

This work was supported by the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry (IPET), through the Crop Viruses and Pests Response Industry Technology Development Program, funded by the Ministry of Agriculture, Food and Rural Affairs (MAFRA) (321108-04).

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Authors and Affiliations

  1. Graduate School of Semiconductor and Chemical Engineering, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do, 54896, Republic of Korea

    Gyeongchan Jeon & Jiho Min

  2. School of Biological Science, Chungbuk National University, Chungdae-ro 1, Seowon-Gu, Cheongju, Chungbuk, 28644, Republic of Korea

    Yang-Hoon Kim

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  1. Gyeongchan Jeon
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  2. Yang-Hoon Kim
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  3. Jiho Min
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Contributions

GJ: conceptualization, methodology, investigation, visualization, writing—original draft, writing—review and editing; Y-HK: supervision, methodology, writing—review and editing; JM: supervision, methodology, writing—review and editing. The manuscript was written through the contributions of all authors. All authors have given approval to the final version of the manuscript.

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Correspondence to Yang-Hoon Kim or Jiho Min.

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Gyeongchan Jeon, Yang-Hoon Kim, and Jiho Min declare that they have no conflict of interest.

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Informed consent was obtained from all individual participants included in the study

Research Involving Human Participants and/or Animals

This article does not contain any studies with human participants or animals performed by any of the authors.

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Jeon, G., Kim, YH. & Min, J. Impact of Lysosomal Fraction on Melanin Synthesis Inhibition in a Zebrafish Melanogenesis Phenotype Model. Mol Biotechnol 64, 1350–1355 (2022). https://doi.org/10.1007/s12033-022-00516-x

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