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Research Progress of LncRNAs in Atrial Fibrillation

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Abstract

Atrial fibrillation (AF) is one of the most common arrhythmias in adults, with high morbidity and increased mortality risk. In recent years, the clinical diagnosis, treatment, and mechanistic research of AF have increased exponentially, and regulation based on the potential molecular mechanism of AF is a research hotspot. Long noncoding RNAs (LncRNAs), usually refer to noncoding RNA transcripts greater than 200 nucleotides in length, have been shown to play a role in cardiovascular diseases such as coronary artery disease, heart failure, and myocardial fibrosis through various regulatory methods. An increasing number of researchers have begun to pay attention to the identification and function of LncRNAs in AF. This article reviews changes in the expression of related LncRNAs detected in AF and describes the LncRNAs that play a regulatory role in AF-related processes, to explore the potential of LncRNAs as new biomarkers and therapeutic targets in AF.

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Acknowledgements

The literature search was completed in June 2021. We apologize to colleagues whose work was not cited in this review due to page limitations. All authors read and approved the final manuscript.

Funding

This research was funded by the Key Specialty of Discipline Construction Project of Shanghai Health Committee (Grant No. ZK2019B25), and the Research Project of Science and Technology Commission of Pudong New Area (Grant No. PKJ2019-Y40).

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Authors and Affiliations

  1. Tongji University School of Medicine, Shanghai, 200082, China

    Wenhui Wang

  2. Department of Cardiology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, No. 1500 of Zhouyuan Road, Pudong New District, Shanghai, 201318, China

    Bei Tian & Zhongping Ning

  3. Shanghai Pudong New Area Center for Disease Control and Prevention, Shanghai, 200136, China

    Xinming Li

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  1. Wenhui Wang
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  2. Bei Tian
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  3. Zhongping Ning
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  4. Xinming Li
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All authors contributed to the study conception and design. WW and BT had the idea for the article, WW performed the literature search and data analysis, ZN and XL critically revised the work. All authors read and approved the final manuscript.

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Correspondence to Xinming Li.

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Wang, W., Tian, B., Ning, Z. et al. Research Progress of LncRNAs in Atrial Fibrillation. Mol Biotechnol 64, 758–772 (2022). https://doi.org/10.1007/s12033-022-00449-5

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