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Modulation of the Immune System Promotes Tissue Regeneration

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Abstract

The immune system plays an essential role in the angiogenesis, repair, and regeneration of damaged tissues. Therefore, the design of scaffolds that manipulate immune cells and factors in such a way that could accelerate the repair of damaged tissues, following implantation, is one of the main goals of regenerative medicine. However, before manipulating the immune system, the function of the various components of the immune system during the repair process should be well understood and the fabrication conditions of the manipulated scaffolds should be brought closer to the physiological state of the body. In this article, we first review the studies aimed at the role of distinct immune cell populations in angiogenesis and support of damaged tissue repair. In the second part, we discuss the use of strategies that promote tissue regeneration by modulating the immune system. Given that various studies have shown an increase in tissue repair rate with the addition of stem cells and growth factors to the scaffolds, and regarding the limited resources of stem cells, we suggest the design of scaffolds that are capable to develop repair of damaged tissue by manipulating the immune system and create an alternative for repair strategies that use stem cells or growth factors.

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Acknowledgements

This study was part of the Ph.D. dissertation supported by the Tehran University of Medical Sciences (Grant No: 98-01-30-41244). The authors would like to acknowledge the Iran National Science Foundation (INSF, Grant No: 98001385) and also, Council for Development of Stem cell Sciences and Technologies (Grant No: 11/35723).

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Authors and Affiliations

  1. Immunology Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Masoomeh Masoomikarimi

  2. Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran

    Majid Salehi

  3. Sexual Health and Fertility Research Center, Shahroud University of Medical Sciences, Shahroud, Iran

    Majid Salehi

  4. Tissue Engineering and Stem Cells Research Center, Shahroud University of Medical Sciences, Shahroud, Iran

    Majid Salehi

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  1. Masoomeh Masoomikarimi
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Correspondence to Majid Salehi.

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Masoomikarimi, M., Salehi, M. Modulation of the Immune System Promotes Tissue Regeneration. Mol Biotechnol 64, 599–610 (2022). https://doi.org/10.1007/s12033-021-00430-8

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