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A Study on the Bending Stiffness of a New DNA Origami Nano-Joint

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Abstract

The present article aims to investigate the mechanical properties of a new DNA origami nano-joint using the steered molecular dynamics (SMD) simulation. Since the analysis of mechanical properties is of great importance in bending conditions for a nano-joint, the forces are selected to achieve angular changes in the joint by the resultant torque. In this study, the nano-joint is considered as a beam in order to use mechanical equations to extract the mechanical properties of the designed nano-joint. In addition, the bending stiffness of the beam is investigated in different modes of deflection using the Euler–Bernoulli beam theory. The results revealed that the value of bending stiffness increases with increasing deflection, and the changes in the bending stiffness relative to the deflection is linear. The proposed DNA origami nano-joint can be used as a joint in nanorobots and can be effectively applied in nanorobotic systems to move different components.

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Authors and Affiliations

  1. Department of Mechanical Engineering, Hakim Sabzevari University, Sabzevar, Iran

    Sadegh Dastorani, Reza Hasanzadeh Ghasemi & Reza Soheilifard

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  1. Sadegh Dastorani
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  2. Reza Hasanzadeh Ghasemi
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  3. Reza Soheilifard
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Correspondence to Reza Hasanzadeh Ghasemi.

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Dastorani, S., Ghasemi, R.H. & Soheilifard, R. A Study on the Bending Stiffness of a New DNA Origami Nano-Joint. Mol Biotechnol 63, 1057–1067 (2021). https://doi.org/10.1007/s12033-021-00367-y

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  • DOI: https://doi.org/10.1007/s12033-021-00367-y

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