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Biosensors for the Diagnosis of Celiac Disease: Current Status and Future Perspectives

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An Erratum to this article was published on 18 June 2016

Abstract

Celiac disease (CD) is an autoimmune enteropathy initiated and sustained by the ingestion of gluten in genetically susceptible individuals. It is caused by a dysregulated immune response toward both dietary antigens, the gluten proteins of wheat, rye, and barley, and autoantigens, the enzyme tissue transglutaminase (TG2). The small intestine is the target organ. Although routine immunochemical protocols for a laboratory diagnosis of CD are available, faster, easier-to-use, and cheaper analytical devices for CD diagnosis are currently unavailable. This review focuses on biosensors, consisting of a physicochemical transducer and a bioreceptor, as promising analytical tools for diagnosis of CD and other diseases. Examples of recently developed biosensors as well as expectations for future lines of research and development in this field are presented.

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Authors and Affiliations

  1. German Research Centre for Food Chemistry, Leibniz Institut, Freising, Germany

    Katharina Anne Scherf

  2. Clinica Medica I, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy

    Rachele Ciccocioppo

  3. Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic

    Miroslav Pohanka

  4. Department of Public Health and Hygiene, Faculty of Medicine, Pavol Jozef Safarik University, Kosice, Slovakia

    Kvetoslava Rimarova

  5. Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic

    Radka Opatrilova

  6. Department of Gastroenterology, Central University Hospital of Asturias (HUCA), Oviedo, Spain

    Luis Rodrigo

  7. Laboratory of Structural Biology and Proteomics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho tr 1946/1, 612 42, Brno, Czech Republic

    Peter Kruzliak

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  1. Katharina Anne Scherf
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  2. Rachele Ciccocioppo
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Scherf, K.A., Ciccocioppo, R., Pohanka, M. et al. Biosensors for the Diagnosis of Celiac Disease: Current Status and Future Perspectives. Mol Biotechnol 58, 381–392 (2016). https://doi.org/10.1007/s12033-016-9940-3

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