Molecular Biotechnology

, Volume 43, Issue 1, pp 89–94

Macromolecular Drug Delivery: Basic Principles and Therapeutic Applications


DOI: 10.1007/s12033-009-9185-5

Cite this article as:
Belting, M. & Wittrup, A. Mol Biotechnol (2009) 43: 89. doi:10.1007/s12033-009-9185-5


Macromolecular drugs hold great promise as novel therapeutics of several major disorders, such as cancer and cardiovascular disease. However, their use is limited by lack of efficient, safe, and specific delivery strategies. Successful development of such strategies requires interdisciplinary collaborations involving researchers with expertise on e.g., polymer chemistry, cell biology, nano technology, systems biology, advanced imaging methods, and clinical medicine. This poses obvious challenges to the scientific community, but also provides opportunities for the unexpected at the interface between different disciplines. This review summarizes recent studies of macromolecular delivery that should be of interest to researchers involved in macromolecular drug synthesis as well as in vitro and in vivo drug delivery studies.


Gene transfer Gene silencing Drug delivery vehicles Endocytosis Peptides Antibodies Cancer Positron emission tomography 

Copyright information

© Humana Press 2009

Authors and Affiliations

  1. 1.Department of Clinical Sciences, Section of OncologyLund UniversityLundSweden

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