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Drug-loaded polymer-coated silver nanoparticles for lung cancer theranostics

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Abstract

Lung cancer is the leading cause of death in cancer across the globe. To minimize these deaths, the replacement of traditional chemotherapy with novel strategies is significant. We have developed a nanotheranostic approach using silver nanoparticles for imaging and treatment. Silver nanoparticles (AgNPs) are fabricated by chemical reduction method. The formulation of AgNPs was confirmed by different characterization techniques like stability test, UV–Visible spectroscopy, Confocal Raman Spectroscopy, and Energy-Dispersive X-ray analysis. Further, AgNPs are coated with poly lactic-co-glycolic acid (PLGA) and then loaded with paclitaxel (Pac). Then the drug-loaded PLGA-coated AgNPs were characterized for size and zeta potential measurement by zetasizer, surface morphology study by atomic force microscopy, Fourier transform infrared spectroscopy, and release kinetics study. The imaging and anticancer properties of these nanoformulations are investigated using lung cancer cell lines. The results proved that the particles are in the nanometer range with smooth surface morphology. Moreover, the drug-loaded NPs showed a sustained release of the drug for a longer period of time. Further the formulations showed imaging property with greater anticancer efficacy. Thus, the results suggest the effective use of these nanoformulation in both lung cancer imaging and treatment using a simple and efficient approach.

Graphical abstract

Schematic representation showing the mechanism of theranostic effect of PLGA coated Pac loaded silver nanoparticles. First silver nanoparticles were formulated then loaded with Pac and coated with PLGA. The formulated nanoparticles will enter into cells by the process of endocytosis and there it will release the drug and the silver. The drug will induce cytotoxicity whereas the silver nanoparticles will be used for imaging purpose.

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Acknowledgements

RM acknowledges to the DST-SERB-TARE (TAR/2021/000137) and UGC-DAE-CRS (CRS/2022-23/954) for funding.

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The authors have not disclosed any funding.

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Authors and Affiliations

  1. Department of Biotechnology, Centre for Research in Pure and Applied Sciences, School of Sciences, Jain University, Bangalore, 560027, Karnataka, India

    Ranjita Misra

  2. Centre for Nanoscience and Nanotechnology, Sathyabama Institute of Science and Technology, Chennai, 600119, India

    Subhenjit Hazra & Sushmitha Nehru

  3. Department of Biotechnology, Indian Institute of Technology, Madras, Chennai, 600036, Tamil Nadu, India

    Suraiya Saleem

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  1. Ranjita Misra
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  2. Subhenjit Hazra
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  3. Suraiya Saleem
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  4. Sushmitha Nehru
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Contributions

RM: designed the whole work and helped in the manuscript writing. SN: did the nanoparticle synthesis and characterization and wrote the manuscript by taking help from RM. SS: has done the cell culture experiments. SH help in silver nanoparticle synthesis.

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Correspondence to Ranjita Misra.

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Misra, R., Hazra, S., Saleem, S. et al. Drug-loaded polymer-coated silver nanoparticles for lung cancer theranostics. Med Oncol 41, 132 (2024). https://doi.org/10.1007/s12032-024-02372-y

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