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How gallic acid regulates molecular signaling: role in cancer drug resistance

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Abstract

Cancer is one of the deadliest and most heterogeneous diseases. Cancers often develop drug resistance, which can lead to treatment failure or recurrence. Accordingly, anticancer compounds are essential for chemotherapy-resistant cancer cells. Phenolic compounds are of interest in the development of cancer drugs due to their medicinal properties and ability to target different molecular pathways. Gallic acid (GA), as one of the main components of phenol, which is abundantly present in plant compounds such as walnut, sumac, grapes, tea leaves, oak bark, and other plant compounds, has antitumor properties. GA can prevent cancer progression, cell invasion, and metastasis by targeting molecular pathways and is an effective complement to chemotherapy drugs and combating multidrug resistance (MDR). In this review, we discuss various mechanisms related to cancer, the therapeutic potential of GA, the antitumor properties of GA in various cancers, and the targeted delivery of GA with nanocarriers.

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Authors and Affiliations

  1. Department of Plant and Animal Biology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran

    Samira Hassani

  2. Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

    Fahimeh Ghanbari

  3. Abortion Research Center, Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Marzieh Lotfi

  4. Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan, 23200, Pakistan

    Waqas Alam & Haroon Khan

  5. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    Michael Aschner

  6. Faculty of Agriculture, Department for Chemistry and Biochemistry, University of Belgrade, Nemanjina 6, 11080, Belgrade, Serbia

    Jelena Popović-Djordjević

  7. Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Marzieh Lotfi & Seyed Hossein Shahcheraghi

  8. Infectious Diseases Research Center, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Seyed Hossein Shahcheraghi

  9. Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Seyed Hossein Shahcheraghi

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Hassani, S., Ghanbari, F., Lotfi, M. et al. How gallic acid regulates molecular signaling: role in cancer drug resistance. Med Oncol 40, 308 (2023). https://doi.org/10.1007/s12032-023-02178-4

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