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Radioprotective effects of gliclazide against irradiation-induced cardiotoxicity and lung injury through inhibiting oxidative stress

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Abstract

Radiotherapy is one of the main treatments for localized primary cancer in patients. Cardiotoxicity and lung injury are two of the main side effects of oxidative stress following radiotherapy in patients with thoracic region cancer. Gliclazide (GLZ) as an antihyperglycemic drug has antioxidant, anti-inflammatory, and anti-apoptotic activities. This study aimed to evaluate the effect of GLZ in cardiotoxicity and lung injury induced by irradiation (IR). In this experimental study, 64 mice were divided into eight groups: control, GLZ (5, 10, and 25 mg/kg), IR (6 Gy), and IR + GLZ (in three doses). GLZ was administrated for 8 consecutive successive days and mice were exposed with IR on the 9th day of study. On the 10th day of study, tissue biochemical assay and at 14th day of study, histopathological assay were performed to evaluate for cardiotoxicity and lung injury. The findings revealed that IR induces atypical features in heart and lung histostructure, and oxidative stress (an increase of MDA, PC levels, and decrease of GSH content) in these tissues. GLZ administration preserved heart and lung damages and improves oxidative stress markers in mice. Data have authenticated that GLZ could protect heart and lung histostructure against oxidative stress-induced injury through inhibiting oxidative stress.

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Data availability

The data sets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

This study was the subject of a Pharm D. thesis of Soroush Arzani as a student of Mazandaran University of Medical Sciences, Sari, Iran.

Funding

This study was supported by a grant from Mazandaran University of Medical Sciences, Sari, Iran (ID#8619). Seyed Jalal Hosseinimehr was received this grant.

Author information

Authors and Affiliations

  1. Department of Anatomy, Faculty of Medicine, Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran

    Fereshteh Talebpour Amiri

  2. Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

    Soroush Arzani & Seyed Jalal Hosseinimehr

  3. Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

    Soroush Arzani

  4. Department of Pharmaceutical Biotechnology, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran

    Soghra Farzipour

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  1. Fereshteh Talebpour Amiri
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Contributions

SJH designed this study. SA, FTA, SF, and SJH contributed to experiments. FTA and SJH designed and wrote the manuscript. All authors read and approved the final manuscript.

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Correspondence to Seyed Jalal Hosseinimehr.

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The authors declare that they have no competing interest.

Ethical approval

This experimental animal study was confirmed by the Research and Ethics Committee of Mazandaran University of Medical Sciences (ID#IR.MAZUMS.REC.1400.8619). All methods were carried out in accordance with relevant guidelines and regulations of University.

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Talebpour Amiri, F., Arzani, S., Farzipour, S. et al. Radioprotective effects of gliclazide against irradiation-induced cardiotoxicity and lung injury through inhibiting oxidative stress. Med Oncol 39, 199 (2022). https://doi.org/10.1007/s12032-022-01803-y

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  • DOI: https://doi.org/10.1007/s12032-022-01803-y

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