Medical Oncology

, 35:140 | Cite as

Human papillomavirus and colorectal cancer

  • Marina K. IbragimovaEmail author
  • Matvey M. Tsyganov
  • Nicolay V. Litviakov
Review Article


The involvement of human papillomavirus in carcinogenesis of colorectal cancer is a contentious issue. The presented meta-analysis was performed to systematize the currently available research results on the matter. The analysis was based on the data from 19 studies to assess the association of HPV infection with colorectal cancer. According to the obtained data, researchers determined the statistically significant level of HPV infection in tumor tissue of CRC and the resulting relative risk of developing CRC with HPV infection to be RR (95% CI) = 2.97 (1.42–6.22) with p = 0.0039.


HPV Colorectal cancer Meta-analysis 


Compliance with ethical standards

Conflict of interest

The authors state that there are no conflicts of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Cancer Research InstituteTomsk National Research Medical Center of the Russian Academy of SciencesTomskRussia
  2. 2.National Research Tomsk State UniversityTomskRussia

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