Medical Oncology

, 35:16 | Cite as

Genetic polymorphisms associated with adverse reactions of molecular-targeted therapies in renal cell carcinoma

  • Kazuhiro YamamotoEmail author
  • Ikuko Yano
Review Article


The prognosis of patients with metastatic renal cell carcinoma has drastically improved due to the development of molecular-targeted drugs and their use in clinical practice. However, these drugs cause some diverse adverse reactions in patients and sometimes affect clinical outcomes of cancer therapy. Therefore, predictive markers are necessary to avoid severe adverse reactions, to establish novel and effective prevention methods, and to improve treatment outcomes. Some genetic factors involved in these adverse reactions have been reported; however, perspectives on each adverse response have not been integrated yet. In this review, genetic polymorphisms relating to molecular-targeted therapy-induced adverse reactions in patients with renal cell carcinoma are summarized in the points of pharmacokinetic and pharmacodynamic mechanisms. We also discuss about the relationship between systemic drug exposure and adverse drug reactions.


Adverse drug reaction Molecular-targeted drug Polymorphism Renal cell carcinoma Pharmacokinetics Pharmacodynamics 



The authors would like to thank Enago ( for the English language review.

Compliance with ethical standards

Conflict of interest

The authors declared no conflicts of interest.

Human and animal rights

This article does not contain any studies with human participants or animals performed by the authors.


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Authors and Affiliations

  1. 1.Department of PharmacyKobe University HospitalKobeJapan

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