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Epithelial-to-mesenchymal transition in tumor progression

Medical Oncology volume 34, Article number: 122 (2017) Cite this article

Abstract

The epithelial-to-mesenchymal transition (EMT) is a biological process in which a non-motile epithelial cell changes to a mesenchymal state with invasive capacities. However, the EMT program is involved in both physiological and pathological processes. Cancer-associated EMT is known to contribute to increase invasiveness and metastasis, resistance to therapies, and generation of cell populations with stem cell-like characteristics and therefore is deeply involved in tumor progression. This process is finely orchestrated by multiple signaling pathways and regulatory transcriptional networks. The hallmark of EMT is the loss of epithelial surface markers, mainly E-cadherin, and the acquisition of mesenchymal phenotype. These events can be mediated by EMT transcription factors which can cooperate with several enzymes to repress the E-cadherin expression and regulate EMT at the epigenetic and post-translational level. A growing body of evidence indicates that cancer cells can reside in various phenotypic states along the EMT spectrum, where cells can jointly retain epithelial traits with mesenchymal ones. This type of phenotypic plasticity endows cancer cells with tumor-initiating potential. The identification of the signaling pathways and modulators that lead to activation of EMT programs during these disease processes is providing new insights into the plasticity of cellular phenotypes and possible therapeutic interventions.

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All the authors gave substantial contributions to the conception and design of the study, data acquisition, and interpretation. They all revised the manuscript and approved the final version.

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  1. Laboratory of Translational Oncology, Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), Avda de Córdoba s/n, 28041, Madrid, Spain

    Elena Prieto-García, C. Vanesa Díaz-García, Inmaculada García-Ruiz & M. Teresa Agulló-Ortuño

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  1. Elena Prieto-García
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Prieto-García, E., Díaz-García, C.V., García-Ruiz, I. et al. Epithelial-to-mesenchymal transition in tumor progression. Med Oncol 34, 122 (2017). https://doi.org/10.1007/s12032-017-0980-8

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Keywords

  • Epithelial-to-mesenchymal transition
  • Tumor progression
  • Regulatory networks