Need for new review of article on ketogenic dietary regimes for cancer patients

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References

  1. 1.

    Erickson N, Boscheri A, Linke B, Huebner J. Systematic review: isocaloric ketogenic dietary regimes for cancer patients. Med Oncol. 2017;34:72.

    CAS  Article  PubMed  Google Scholar 

  2. 2.

    Allen BG, Bhatia SK, Anderson CM, Eichenberger-Gilmore JM, Sibenaller ZA, Mapuskar KA, et al. Ketogenic diets as an adjuvant cancer therapy: history and potential mechanism. Redox Biol. 2014;2C:963–70.

    Article  Google Scholar 

  3. 3.

    Fine EJ, Feinman RD. Insulin, carbohydrate restriction, metabolic syndrome and cancer. Exp Rev Endocrin Metab. 2014;10:15–24.

    Article  Google Scholar 

  4. 4.

    Winter SF, Loebel F, Dietrich J. Role of ketogenic metabolic therapy in malignant glioma: a systematic review. Crit Rev Oncol Hematol. 2017;112:41–58.

    Article  PubMed  Google Scholar 

  5. 5.

    Seyfried TN, Flores R, Poff AM, D’Agostino DP, Mukherjee P. Metabolic therapy: a new paradigm for managing malignant brain cancer. Cancer Lett. 2015;356:289–300.

    CAS  Article  PubMed  Google Scholar 

  6. 6.

    Klement RJ, Fink MK. Dietary and pharmacological modification of the insulin/IGF-1 system: exploiting the full repertoire against cancer. Oncogenesis. 2016;5:e193.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  7. 7.

    Tan-Shalaby JL, Carrick J, Edinger K, Genovese D, Liman AD, Passero VA, et al. Modified Atkins diet in advanced malignancies: final results of a safety and feasibility trial within the Veterans Affairs Pittsburgh Healthcare System. Nutr Metab. 2016;13:52.

    Article  Google Scholar 

  8. 8.

    Barber MD, McMillan DC, Preston T, Ross JA, Fearon KC. Metabolic response to feeding in weight-losing pancreatic cancer patients and its modulation by a fish-oil-enriched nutritional supplement. Clin Sci. 2000;98:389–99.

    CAS  Article  PubMed  Google Scholar 

  9. 9.

    Shukla SK, Gebregiworgis T, Purohit V, Chaika NV, Gunda V, Radhakrishnan P, et al. Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia. Cancer Metab. 2014;2:18.

    Article  PubMed  PubMed Central  Google Scholar 

  10. 10.

    Abdelwahab MG, Fenton KE, Preul MC, Rho JM, Lynch A, Stafford P, et al. The ketogenic diet is an effective adjuvant to radiation therapy for the treatment of malignant glioma. PLoS ONE. 2012;7:e36197.

    Article  PubMed  PubMed Central  Google Scholar 

  11. 11.

    Klement RJ, Sweeney R. Impact of a ketogenic diet intervention during radiotherapy on body composition: I. Initial clinical experience with six prospectively studied patients. BMC Res Notes. 2016;9:143.

    Article  PubMed  PubMed Central  Google Scholar 

  12. 12.

    Nebeling L, Miraldi F, Shurin S, Lerner E. Effects of a ketogenic diet on tumor metabolism and nutritional status in pediatric oncology patients: two case reports. J Am Coll Nutr. 1995;14:202–8.

    CAS  Article  PubMed  Google Scholar 

  13. 13.

    Jansen N, Walach H. The development of tumours under a ketogenic diet in association with the novel tumour marker TKTL1: a case series in general practice. Oncol Lett. 2016;11:584–92.

    PubMed  Google Scholar 

  14. 14.

    Ioannidis JPA. Meta-research: the art of getting it wrong. Res Synth Methods. 2010;1:169–84.

    Article  PubMed  Google Scholar 

  15. 15.

    Feinman RD, Keough SM. Ethics in medical research and the low-fat diet-heart hypothesis. Ethics Biol Eng Med. 2015;5:149–59.

    Article  Google Scholar 

  16. 16.

    Horton R. Offline: What is medicine’s 5 sigma? Lancet. 2015;385:1380.

    Article  Google Scholar 

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Acknowledgements

U. Kämmerer has received Grants from the German Society for Clinical Nutrition (DGEM) for her research. A. Poff is a scientific advisor for Pruvit Ventures, LLC, and holds a patent “Targeting Cancer with Metabolic Therapy and Hyperbaric Oxygen” (#PCT/US2013/072333). D. P. D’Agostino holds a patent “Targeting cancer with metabolic therapy” (#USF/WO2014085652AI).

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Correspondence to Rainer J. Klement.

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Klement, R.J., Feinman, R.D., Gross, E.C. et al. Need for new review of article on ketogenic dietary regimes for cancer patients. Med Oncol 34, 108 (2017). https://doi.org/10.1007/s12032-017-0968-4

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Keywords

  • Ketogenic Diet
  • Preliminary Clinical Result
  • Relative Insulin Deficiency
  • Trained Dietician
  • Epilepsy Therapy