Abstract
Germ cell tumors (GCTs) are one of the more curable solid cancers in men. Approximately 8500 men are diagnosed with GCTs in the USA. The majority of patients survive due to the availability of effective treatment. Fewer than 400 men are estimated to die from their disease. Among those, there is a subset of patients with metastatic GCTs receiving chemotherapy who rapidly develop progressive respiratory failure and die during the early phase of their treatment course. In this review, we searched the available literature for reported cases and retrospective series of chemotherapy-associated acute respiratory distress syndrome in GCTs. We aim to determine whether a different approach from current treatment guidelines could be considered to prevent this catastrophic chemotherapy-related event.
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Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65:5.
McGowan MP, Pratter MR, Nash G. Primary testicular choriocarcinoma with pulmonary metastases presenting as ARDS. Chest. 1990;97(5):1258–9.
Moran-Ribon A, Droz JP, Kattan J, et al. Super-high-risk germ-cell tumors: a clinical entity. Report of eleven cases. Support Care Cancer. 1994;2:253–8.
Kirch C, Blot F, Fizazi K, et al. Acute respiratory distress syndrome after chemotherapy for lung metastases from non-seminomatous germ-cell tumors. Support Care Cancer. 2003;11:575–80.
Gullessen S, Powles T, Lim L, et al. Low dose induction chemotherapy with baby-BOP in patients with metastatic germ cell tumours does not compromise outcome: a single centre experience. Ann Oncol. 2010. doi:10.1093/annonc/mdq019.
Massard C, Plantade A, Gross-Goupil M, et al. Poor-prognosis non-seminomatous germ cell tumors (NSGCT): should chemotherapy doses be reduced at first cycle to prevent acute respiratory distress. Ann Oncol. 2010. doi:10.1093/annonc/mdq021.
Boeck S, Metzeler KH, Hausmann A, et al. Cisplatin-based chemotherapy for pulmonary metastasized germ cell tumors of the testis—be aware of acute respiratory distress syndrome. Onkologie. 2009;32(3):125–8.
Kobatake K, Kato M, Mita K. Advanced testicular cancer associated with life-threatening tumour lysis syndrome and choriocarcinoma syndrome. Can Urol Assoc J. 2015;9(1–2):62–4. doi:10.5489/cuaj.2499.
Oshima J, Uemura M, Kato T, et al. Modified BEP regimen leads to abatement of choriocarcinoma syndrome in a patient with extra gonadal germ cell tumor: a case report. Hinyokika Kiyo. 2014;60(4):183–7.
Mazur MT, Lurain JR, Brewer JI. Fatal gestational choriocarcinoma. Clinicopathologic study of patients treated at a trophoblastic disease center. Cancer. 1982;50(9):1833–46.
Fizazi K, Massard C, Postel-Vinay S, et al. Chemotherapy for poor prognosis non seminomatous germ cell tumors (NSGCT): should doses be reduced at first cycle to prevent acute respiratory distress syndrome (ARDS) in patients with multiple lung metastases? J Clin Oncol. 2007;25(18_Suppl):5087.
Krege S, Beyer J, Souchon R, et al. European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus group (EGCCCG): part I + II. Eur Urol. 2008;53(3):478–513.
Mohler JL, Armstrong AJ, Bahnson RR, et al. Prostate cancer, version 3.2012 featured updates to the NCCN guidelines. J Natl Compr Cancer Netw. 2012;10(9):1081–7.
Author’s contribution
MA is the main author of the review article. As a corresponding author, he has substantial contributions in designing this manuscript, searched for English-written literature, prepared the draft, revised it critically for its content, edited, and approved the final version. He agreed to be accountable for all aspects of this manuscript. NE searched for English-written literature and edited the final draft of the manuscript. She has substantial contributions in designing this manuscript. She revised it critically for its content and approved final version to be published. She agreed to be accountable for all aspects of this manuscript. MMH searched for English-written literature and edited the final draft of the manuscript. She has substantial contributions in designing this manuscript. She revised it critically for its content and approved final version to be published. She agreed to be accountable for all aspects of this manuscript. HB searched for English-written literature and edited the final draft of the manuscript. He has substantial contributions in designing this manuscript and also searched for English-written literature about the subject. He revised it critically for its content and approved final version to be published. He agreed to be accountable for all aspects of this manuscript.
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Alsharedi, M., Elmsherghi, N., Haydock, M.M. et al. Chemotherapy-related acute respiratory distress syndrome in germ cell tumors: a literature review. Med Oncol 34, 56 (2017). https://doi.org/10.1007/s12032-017-0913-6
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DOI: https://doi.org/10.1007/s12032-017-0913-6