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Intra-articular benign bone lesions treated with Magnetic Resonance-guided Focused Ultrasound (MRgFUS): imaging follow-up and clinical results

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Abstract

Purpose of this study was to evaluate the employment of MRI-guided Focused Ultrasound (MRgFUS) for treatment of intra-articular benign bone lesions as alternative to surgery, and to monitor the success of the treatment on CT and MRI images. From March 2011 to August 2013, 14 intra-articular benign bone lesions were treated with MRgFUS. All patients were studied by CT and MR imaging. Pain was measured using the visual analogue scale (VAS) before and after treatment (6 and 12 months). All patients in our series demonstrated regression in painful symptomatology during screening. A significant drop in the mean VAS pain score (from 7.8 to 0.6) was observed at 12-month follow-up, and pain medication was no longer needed after treatment. No complications were observed. Three diagnostic imaging signs were found suggesting absence of biological activity and confirming the clinical findings: calcification of the treated lesion, lack of contrast enhancement and disappearance of bone oedema around the lesions. Conclusion: the employment of MRgFUS is safe and effective in the treatment of intra-articular benign bone lesions. The clinical outcome is satisfactory, and the success of the treatment is confirmed by diagnostic imaging.

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Acknowledgement

We are grateful to Angela Martella for translation of the manuscript.

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Authors and Affiliations

  1. Diagnostic and Interventional Radiology, Department of Applied Clinical Science and Biotechnology, University of L’Aquila, L’Aquila, Italy

    Francesco Arrigoni, Antonio Barile, Luigi Zugaro, Alessandra Splendiani, Ernesto Di Cesare & Carlo Masciocchi

  2. Department of Medicine and Health Science “V. Tiberio”, University of Molise, Campobasso, Italy

    Ferdinando Caranci & Luca Brunese

  3. Department of Radiology, Insubria University, Varese, Italy

    Anna Maria Ierardi & Chiara Floridi

  4. Diagnostic and Interventional Radiology Unit, University of Milan, Milan, Italy

    Alessio Salvatore Angileri

  5. Department of Internal and Experimental Medicine, Magrassi-Lanzara, Institute of Radiology, Second University of Naples, Naples, Italy

    Alfonso Reginelli

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  1. Francesco Arrigoni
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Correspondence to Francesco Arrigoni.

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All procedures performed in these studies were in accordance with the Helsinki Declaration and its later amendments; an informed consent was obtained from all individual participants included in the study.

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Arrigoni, F., Barile, A., Zugaro, L. et al. Intra-articular benign bone lesions treated with Magnetic Resonance-guided Focused Ultrasound (MRgFUS): imaging follow-up and clinical results. Med Oncol 34, 55 (2017). https://doi.org/10.1007/s12032-017-0904-7

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