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Simultaneous PET/MRI assessment of response to cytotoxic and hormone neo-adjuvant chemotherapy in breast cancer: a preliminary report

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Abstract

The aim of this study was to assess the response to cytotoxic and hormone neo-adjuvant chemotherapy in four patients with locally advanced breast cancer by simultaneous PET/MRI. Four patients with locally advanced breast cancer underwent simultaneous PET/MRI of the breast using a 3 T Biograph mMR before and after neo-adjuvant chemotherapy (two patients were treated with hormone-therapy and two patients were treated with cytotoxic chemotherapy). Morpho-structural tumoral features and tumor size were assessed; area value, metabolic (SUV and MTV) and functional (ADC, K trans, V e, k ep and iAUC) data were obtained by positioning regions of interest. A comparison of all parameters between the pre- and post-treatment PET/MRI examinations and between the two different therapeutic schedules was assessed. In patients treated with cytotoxic chemotherapy and classified as PR, there was a significant reduction of post-treatment morphological, metabolic and functional parameters. In a patient treated with hormone therapy, classified as SD, there was an increase of all post-treatment perfusion parameters, a substantially stable ADC value and a poor reduction of lesion size and of maximum SUV (SUVmax) values; the last patient, treated with hormone therapy and classified as PR, showed a significant reduction of lesion size and SUVmax values with a reduction of perfusion parameters and substantially stable ADC values. Multiparametric evaluation with simultaneous PET/MRI could be a useful tool to assess the response to cytotoxic and hormone neo-adjuvant chemotherapy in patients with breast cancer. Future studies in a larger cohort of patients are warranted to confirm the results of this preliminary study.

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Authors and Affiliations

  1. Department of Advanced Biomedical Sciences, University Federico II of Naples, Via S. Pansini, 5, 80123, Naples, Italy

    Valeria Romeo & Massimo Imbriaco

  2. Breast Department, National Cancer Institute of Naples IRCCS “G. Pascale”, Naples, Italy

    Massimiliano D’Aiuto & Giuseppe Frasci

  3. IRCCS SDN, Naples, Italy

    Emanuele Nicolai

Authors
  1. Valeria Romeo
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  2. Massimiliano D’Aiuto
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  3. Giuseppe Frasci
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  4. Massimo Imbriaco
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  5. Emanuele Nicolai
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Correspondence to Valeria Romeo.

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The authors declare that they have no conflict of interest.

Ethical standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Romeo, V., D’Aiuto, M., Frasci, G. et al. Simultaneous PET/MRI assessment of response to cytotoxic and hormone neo-adjuvant chemotherapy in breast cancer: a preliminary report. Med Oncol 34, 18 (2017). https://doi.org/10.1007/s12032-016-0876-z

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  • DOI: https://doi.org/10.1007/s12032-016-0876-z

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