Medical Oncology

, 33:67 | Cite as

ABO blood groups in relation to breast carcinoma incidence and associated prognostic factors in Moroccan women

  • S. ZouineEmail author
  • F. Marnissi
  • N. Otmani
  • M. Bennani Othmani
  • M. El Wafi
  • K. Kojok
  • Y. Zaid
  • N. Tahiri Jouti
  • N. Habti
Original Paper


The association between blood groups ABO and different types of diseases was established in several previous studies. Our aim was to seek the possible association between the ABO blood group and breast cancer-associated prognostic factors. The Chi-squared analytic test was used to compare phenotypic ABO distribution among Moroccan blood donors and 442 cases of women suffering from breast carcinoma with archived files in Maternity Ward of University Hospital C.H.U Ibn Rochd between 2008 and 2011. High incidence of breast carcinoma was observed in blood type B patients (p < 0.05). Blood type B was associated with breast carcinomas overexpressing human epidermal growth factor receptor HER2 (p < 0.05) and high risk of cancer at age over 70 years (p < 0.001). Blood type A was associated with high risk of cancer among women younger than 35 years old. Blood type A and AB were associated with high incidence of lymph node metastasis (p < 0.05). Multivariate analysis has shown correlation between O blood type and estrogen receptor-positive tumor. Patients with blood group A, B, and AB were more likely to develop aggressive breast carcinoma. Further follow-up studies are necessary to clarify the role of ABH antigens in the progression of breast carcinoma.


ABO blood group Breast carcinoma Age at diagnosis Human epidermal growth factor receptor 2 Lymph node metastasis Estrogen receptor 



Centre Hospitalier Universitaire


Estrogen receptor


Human epidermal growth factor receptor 2


Progesterone receptor


Scraff Bloom and Richardson histological grading


Soluble intercellular adhesion molecule-1


Single nucleotide polymorphism


Tumor necrosis factor-alpha


Von Willebrand factor



We are extremely grateful to Pr S. Zamiati who has facilitated us access to Pathology Department and Pr M. Matar who has facilitated us access to Maternity Ward L 9 C.H.U Ibn Rochd Casablanca. We thank all the team of Pathology Department C.H.U Ibn Rochd in Casablanca: Pr S. Benayad; residents; secretary; and technicians for their kind helping and encouragement.

Author contributions

SZ, FM, MEW, NTJ, and NH participated in the design of the study. SZ and NH interpreted results and wrote the paper. NO and MBO performed the statistical analysis. All authors have read and approved the final version of the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare having no conflict of interests.


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • S. Zouine
    • 1
    • 2
    Email author
  • F. Marnissi
    • 3
  • N. Otmani
    • 4
  • M. Bennani Othmani
    • 4
  • M. El Wafi
    • 1
    • 2
  • K. Kojok
    • 5
  • Y. Zaid
    • 5
  • N. Tahiri Jouti
    • 6
  • N. Habti
    • 1
    • 2
  1. 1.Laboratory of Biotechnology and Experimental Medicine, Faculty of Medicine and Pharmacy CasablancaHassan II University of CasablancaCasablancaMorocco
  2. 2.Laboratory of Hematology, Cellular and Genetic Engineering, Faculty of Medicine and Pharmacy CasablancaHassan II University of CasablancaCasablancaMorocco
  3. 3.Pathology DepartmentUniversity Hospital Ibn Rochd CasablancaCasablancaMorocco
  4. 4.Laboratory of Medical Informatics, Faculty of Medicine and Pharmacy of CasablancaHassan II University of CasablancaCasablancaMorocco
  5. 5.Laboratory of Thrombosis and HemostasisMontreal Heart InstituteMontrealCanada
  6. 6.Pathology Laboratory, Faculty of Medicine and Pharmacy of CasablancaHassan II University of CasablancaCasablancaMorocco

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