Skip to main content

Advertisement

SpringerLink
Log in

ABO blood groups in relation to breast carcinoma incidence and associated prognostic factors in Moroccan women

  • Original Paper
  • Published:
Medical Oncology Aims and scope Submit manuscript

Abstract

The association between blood groups ABO and different types of diseases was established in several previous studies. Our aim was to seek the possible association between the ABO blood group and breast cancer-associated prognostic factors. The Chi-squared analytic test was used to compare phenotypic ABO distribution among Moroccan blood donors and 442 cases of women suffering from breast carcinoma with archived files in Maternity Ward of University Hospital C.H.U Ibn Rochd between 2008 and 2011. High incidence of breast carcinoma was observed in blood type B patients (p < 0.05). Blood type B was associated with breast carcinomas overexpressing human epidermal growth factor receptor HER2 (p < 0.05) and high risk of cancer at age over 70 years (p < 0.001). Blood type A was associated with high risk of cancer among women younger than 35 years old. Blood type A and AB were associated with high incidence of lymph node metastasis (p < 0.05). Multivariate analysis has shown correlation between O blood type and estrogen receptor-positive tumor. Patients with blood group A, B, and AB were more likely to develop aggressive breast carcinoma. Further follow-up studies are necessary to clarify the role of ABH antigens in the progression of breast carcinoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

Abbreviations

CHU:

Centre Hospitalier Universitaire

ER:

Estrogen receptor

HER2:

Human epidermal growth factor receptor 2

PR:

Progesterone receptor

SBR:

Scraff Bloom and Richardson histological grading

SICAM-1:

Soluble intercellular adhesion molecule-1

SNP:

Single nucleotide polymorphism

TNF-α:

Tumor necrosis factor-alpha

VWF:

Von Willebrand factor

References

  1. Eastlund T. The histo-blood group ABO system and tissue transplantation. Transfusion. 1998;38(10):975–88.

    Article  CAS  PubMed  Google Scholar 

  2. Ravn V, Dabelsteen E. Tissue distribution of histo-blood group antigens. APMIS. 2000;108(1):1–28.

    Article  CAS  PubMed  Google Scholar 

  3. Yamamoto F, et al. Molecular genetic basis of the histo-blood group ABO system. Nature. 1990;345(6272):229–33.

    Article  CAS  PubMed  Google Scholar 

  4. Yamamoto F, et al. Cloning and characterization of DNA complementary to human UDP-GalNAc: Fuc alpha 1—2Gal alpha 1—3GalNAc transferase (histo-blood group A transferase) mRNA. J Biol Chem. 1990;265(2):1146–51.

    CAS  PubMed  Google Scholar 

  5. Simoneau M, et al. Chromosome 9 deletions and recurrence of superficial bladder cancer: identification of four regions of prognostic interest. Oncogene. 2000;19(54):6317–23.

    Article  CAS  PubMed  Google Scholar 

  6. Baudis M. Genomic imbalances in 5918 malignant epithelial tumors: an explorative meta-analysis of chromosomal CGH data. BMC Cancer. 2007;7:226.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Rakosy Z, et al. Characterization of 9p21 copy number alterations in human melanoma by fluorescence in situ hybridization. Cancer Genet Cytogenet. 2008;182(2):116–21.

    Article  CAS  PubMed  Google Scholar 

  8. Vogel F. Controversy in human genetics. ABO blood groups and disease. Am J Hum Genet. 1970;22(4):464–75.

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Costantini M, et al. Role of blood groups as prognostic factors in primary breast cancer. Oncology. 1990;47(4):308–12.

    Article  CAS  PubMed  Google Scholar 

  10. Mourali N, et al. Epidemiologic features of rapidly progressing breast cancer in Tunisia. Cancer. 1980;46(12):2741–6.

    Article  CAS  PubMed  Google Scholar 

  11. Habti N, Nourichafi N, Benchemsi N. ABO polymorphism in blood donors in Morocco. Transfus Clin Biol. 2004;11(2):95–7.

    Article  CAS  PubMed  Google Scholar 

  12. Jemal A, et al. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69–90.

    Article  PubMed  Google Scholar 

  13. Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol. 2006;24(14):2137–50.

    Article  PubMed  Google Scholar 

  14. Annese V, et al. ABO blood groups and cancer of the pancreas. Int J Pancreatol. 1990;6(2):81–8.

    CAS  PubMed  Google Scholar 

  15. Su M, et al. Relationship between ABO blood groups and carcinoma of esophagus and cardia in Chaoshan inhabitants of China. World J Gastroenterol. 2001;7(5):657–61.

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Aird I, Bentall HH, Roberts JA. A relationship between cancer of stomach and the ABO blood groups. Br Med J. 1953;1(4814):799–801.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Aird I, Lee DR, Roberts JA. ABO blood groups and cancer of oesophagus, cancer of pancreas, and pituitary adenoma. Br Med J. 1960;1(5180):1163–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Anderson DE, Haas C. Blood type A and familial breast cancer. Cancer. 1984;54(9):1845–9.

    Article  CAS  PubMed  Google Scholar 

  19. Pandey M, Gautam A, Shukla VK. ABO and Rh blood groups in patients with cholelithiasis and carcinoma of the gall bladder. BMJ. 1995;310(6995):1639.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Iodice S, et al. ABO blood group and cancer. Eur J Cancer. 2010;46(18):3345–50.

    Article  CAS  PubMed  Google Scholar 

  21. Ben Q, et al. Pancreatic cancer incidence and outcome in relation to ABO blood groups among Han Chinese patients: a case–control study. Int J Cancer. 2011;128(5):1179–86.

    Article  CAS  PubMed  Google Scholar 

  22. Yuzhalin AE, Kutikhin AG. ABO and Rh blood groups in relation to ovarian, endometrial and cervical cancer risk among the population of South-East Siberia. Asian Pac J Cancer Prev. 2012;13(10):5091–6.

    Article  PubMed  Google Scholar 

  23. Rahbari NN, et al. AB0 blood group and prognosis in patients with pancreatic cancer. BMC Cancer. 2012;12:319.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Poole EM, et al. ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium. Cancer Causes Control. 2012;23(11):1805–10.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Wang DS, et al. ABO blood group, hepatitis B viral infection and risk of pancreatic cancer. Int J Cancer. 2012;131(2):461–8.

    Article  CAS  PubMed  Google Scholar 

  26. Wang Z, et al. ABO blood group system and gastric cancer: a case-control study and meta-analysis. Int J Mol Sci. 2012;13(10):13308–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Woo SM, et al. Risk of pancreatic cancer in relation to ABO blood group and hepatitis C virus infection in Korea: a case–control study. J Korean Med Sci. 2013;28(2):247–51.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Hsiao LT, et al. ABO blood group and the risk of cancer among middle-aged people in Taiwan. Asia Pac J Clin Oncol. 2015;11(4):31–6.

    Article  Google Scholar 

  29. Zhang BL, et al. ABO blood groups and risk of cancer: a systematic review and meta-analysis. Asian Pac J Cancer Prev. 2014;15(11):4643–50.

    Article  PubMed  Google Scholar 

  30. Etemadi A, et al. Mortality and cancer in relation to ABO blood group phenotypes in the Golestan Cohort Study. BMC Med. 2015;13:8.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Vioque J, Walker AM. Pancreatic cancer and ABO blood types: a study of cases and controls. Med Clin (Barc). 1991;96(20):761–4.

    CAS  Google Scholar 

  32. Torti RA. ABO blood groups and Rh. Antigens in patients with carcinoma of the breast. Med Times. 1963;91:1167–8.

    CAS  PubMed  Google Scholar 

  33. Rai S, et al. ABO blood group distribution in carcinoma of the breast. Indian J Cancer. 1970;7(2):135–9.

    CAS  PubMed  Google Scholar 

  34. Newell GR, et al. ABO blood groups and cancer. J Natl Cancer Inst. 1974;52(5):1425–30.

    CAS  PubMed  Google Scholar 

  35. Munzarova M, et al. Course of breast cancer disease and ABO blood groups. Biomed Pharmacother. 1985;39(9–10):486–9.

    CAS  PubMed  Google Scholar 

  36. Dede DS, et al. Blood ABO groups and risk of breast cancer. Med Oncol. 2010;27(4):1433.

    Article  PubMed  Google Scholar 

  37. Khalili H, et al. ABO blood group and risk of colorectal cancer. Cancer Epidemiol Biomark Prev. 2011;20(5):1017–20.

    Article  CAS  Google Scholar 

  38. Joh HK, Cho E, Choueiri TK. ABO blood group and risk of renal cell cancer. Cancer Epidemiol. 2012;36(6):528–32.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Gates MA, et al. ABO blood group and breast cancer incidence and survival. Int J Cancer. 2012;130(9):2129–37.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Teresa DB, et al. Polymorphisms of Lewis and Secretor genes are related to breast cancer and metastasis in axillary lymph nodes. Tumour Biol. 2010;31(5):401–9.

    Article  CAS  PubMed  Google Scholar 

  41. Klimant E, et al. Blood type, hormone receptor status, HER2/neu status, and survival in breast cancer: a retrospective study exploring relationships in a phenotypically well-defined cohort. Clin Med Res. 2011;9(3–4):111–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Ross JS, Fletcher JA. The HER-2/neu oncogene in breast cancer: prognostic factor, predictive factor, and target for therapy. Oncologist. 1998;3(4):237–52.

    PubMed  Google Scholar 

  43. Holdsworth PJ, et al. Blood group as a prognostic indicator in breast cancer. Br Med J (Clin Res Ed). 1985;290(6469):671–3.

    Article  CAS  Google Scholar 

  44. Marionneau S, Le Moullac-Vaidye B, Le Pendu J. Expression of histo-blood group A antigen increases resistance to apoptosis and facilitates escape from immune control of rat colon carcinoma cells. Glycobiology. 2002;12(12):851–6.

    Article  CAS  PubMed  Google Scholar 

  45. Carey LA, et al. Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA. 2006;295(21):2492–502.

    Article  CAS  PubMed  Google Scholar 

  46. Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010;140(6):883–99.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Balkwill F. Tumour necrosis factor and cancer. Nat Rev Cancer. 2009;9(5):361–71.

    Article  CAS  PubMed  Google Scholar 

  48. Melzer D, et al. A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet. 2008;4(5):e1000072.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Gearing AJ, Newman W. Circulating adhesion molecules in disease. Immunol Today. 1993;14(10):506–12.

    Article  CAS  PubMed  Google Scholar 

  50. Pare G, et al. Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6578 women. PLoS Genet. 2008;4(7):e1000118.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Barbalic M, et al. Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels. Hum Mol Genet. 2010;19(9):1863–72.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Ruggeri ZM. Structure and function of von Willebrand factor: relationship to von Willebrand’s disease. Mayo Clin Proc. 1991;66(8):847–61.

    Article  CAS  PubMed  Google Scholar 

  53. Gordon JL, et al. Plasma von Willebrand factor in connective tissue disease. Ann Rheum Dis. 1987;46(6):491–2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. Franchini M, et al. von Willebrand factor and cancer: a renewed interest. Thromb Res. 2013;131(4):290–2.

    Article  CAS  PubMed  Google Scholar 

  55. Gill JC, et al. The effect of ABO blood group on the diagnosis of von Willebrand disease. Blood. 1987;69(6):1691–5.

    CAS  PubMed  Google Scholar 

Download references

Acknowledgments

We are extremely grateful to Pr S. Zamiati who has facilitated us access to Pathology Department and Pr M. Matar who has facilitated us access to Maternity Ward L 9 C.H.U Ibn Rochd Casablanca. We thank all the team of Pathology Department C.H.U Ibn Rochd in Casablanca: Pr S. Benayad; residents; secretary; and technicians for their kind helping and encouragement.

Author contributions

SZ, FM, MEW, NTJ, and NH participated in the design of the study. SZ and NH interpreted results and wrote the paper. NO and MBO performed the statistical analysis. All authors have read and approved the final version of the manuscript.

Author information

Authors and Affiliations

  1. Laboratory of Biotechnology and Experimental Medicine, Faculty of Medicine and Pharmacy Casablanca, Hassan II University of Casablanca, 19 Rue Tarik Ibnou Ziad, B.P. 9154, 20000, Casablanca, Morocco

    S. Zouine, M. El Wafi & N. Habti

  2. Laboratory of Hematology, Cellular and Genetic Engineering, Faculty of Medicine and Pharmacy Casablanca, Hassan II University of Casablanca, Casablanca, Morocco

    S. Zouine, M. El Wafi & N. Habti

  3. Pathology Department, University Hospital Ibn Rochd Casablanca, Casablanca, Morocco

    F. Marnissi

  4. Laboratory of Medical Informatics, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca, Casablanca, Morocco

    N. Otmani & M. Bennani Othmani

  5. Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, Montreal, QC, Canada

    K. Kojok & Y. Zaid

  6. Pathology Laboratory, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca, Casablanca, Morocco

    N. Tahiri Jouti

Authors
  1. S. Zouine
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. Marnissi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. Otmani
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Bennani Othmani
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. El Wafi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. K. Kojok
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Y. Zaid
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. N. Tahiri Jouti
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. N. Habti
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. Zouine.

Ethics declarations

Conflict of interest

The authors declare having no conflict of interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zouine, S., Marnissi, F., Otmani, N. et al. ABO blood groups in relation to breast carcinoma incidence and associated prognostic factors in Moroccan women. Med Oncol 33, 67 (2016). https://doi.org/10.1007/s12032-016-0784-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s12032-016-0784-2

Keywords

Search

Navigation