Medical Oncology

, 33:68 | Cite as

The role of IL-37 in cancer

  • Vivi A. Ding
  • Ziwen Zhu
  • Huaping Xiao
  • Mark R. Wakefield
  • Qian Bai
  • Yujiang FangEmail author
Review Article


Interleukin 37 (IL-37) is a new member of the IL-1 family which all have a similar β-barrel structure. Since its discovery, IL-37 has been studied extensively in immunological field. It has been established that IL-37 possesses anti-inflammatory characteristics both in innate immune response as well as in acquired immune responses by downregulating pro-inflammatory molecules. This review will discuss the role of IL-37 in immunological processes and neoplastic pathogenesis.


IL-37 Immunity Cancer 



This study was supported by grants from Des Moines University for Yujiang Fang (IOER 05-14-01, IOER 112-3749, and IOER 112-3114).

Compliance with ethical standards

Conflict of interest

The authors have no conflict of interest.


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Vivi A. Ding
    • 1
  • Ziwen Zhu
    • 2
  • Huaping Xiao
    • 3
  • Mark R. Wakefield
    • 2
  • Qian Bai
    • 2
  • Yujiang Fang
    • 1
    • 2
    Email author
  1. 1.Department of Microbiology, Immunology & PathologyDes Moines UniversityDes MoinesUSA
  2. 2.Department of SurgeryUniversity of Missouri School of MedicineColumbiaUSA
  3. 3.The Affiliated Hospital of Xiangnan UniversityChenzhouChina

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