Skip to main content

Advertisement

SpringerLink
Log in

Uveitis and T cell lymphoma: a rare but notable relationship

  • Original Paper
  • Published:
Medical Oncology Aims and scope Submit manuscript

Abstract

Uveitis is an autoimmune disease of the eye that refers to a number of intraocular inflammatory conditions. We identified three rare cases of T cell lymphoma diagnosed following an initial presentation of uveitis. This study summarized the clinical features of these rare cases and evaluated the association between uveitis and lymphoma. We analyzed the etiology of uveitis diagnosed in the Department of Pediatrics and Internal Medicine at our hospital. Five patients were diagnosed with uveitis and lymphoma. We present case reports of three patients who were diagnosed with T cell lymphoma following an initial presentation of uveitis. From January 1985 to June 2013, there were 80 cases of uveitis and 1,900 cases of lymphoma in the Department of Pediatrics and Internal Medicine at our hospital. We found five patients that were diagnosed with uveitis and lymphoma; of these, three had a definite pathologic diagnosis of T cell lymphoma. The odds ratio (OR) was 6.08 (95 % confidence interval [CI] of 1.93–14.94, P = 0.002) for the five patients with uveitis and lymphoma, suggesting a significant association. The OR was 3.67 (95 % CI of 1.16–11.65, P = 0.053) for the three patients with uveitis and T cell lymphoma. Uveitis may be a rare presentation of malignant disease, such as lymphoma. Ophthalmologists and general practitioners should be familiar with the differential diagnosis of uveitis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Barisani-Asenbauer T, Maca SM, Mejdoubi L, Emminger W, Machold K, Auer H. Uveitis- a rare disease often associated with systemic diseases and infections- a systematic review of 2619 patients. Orphanet J Rare Dis. 2012;7:57.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Gunduz E, Korkmaz C, Kasifoglu T, Gulbas Z. Unusual presentation of non-Hodgkin lymphoma: polyarthritis and uveitis mimicking a rheumatologic disease. Rheumatol Int. 2008;28:613–4.

    Article  PubMed  Google Scholar 

  3. Armitage JO. The aggressive peripheral T-cell lymphomas: 2012 update on diagnosis, risk stratification, and management. Am J Hematol. 2012;87:511–9.

    Article  PubMed  Google Scholar 

  4. Davis JL, Ruiz P Jr, Shah M, Mandelcorn ED. Evaluation of the reactive T-cell infiltrate in uveitis and intraocular lymphoma with flow cytometry of vitreous fluid (an American ophthalmological society thesis). Trans Am Ophthalmol Soc. 2012;110:117–29.

    PubMed Central  PubMed  Google Scholar 

  5. Levy-Clarke GA, Greenman D, Sieving PC, Byrnes G, Shen D, Nussenblatt R, et al. Ophthalmic manifestations, cytology, immunohistochemistry, and molecular analysis of intraocular metastatic T-cell lymphoma: report of a case and review of the literature. Surv Ophthalmol. 2008;53(3):285–95.

    Article  PubMed Central  PubMed  Google Scholar 

  6. Hoffman PM, McKelvie P, Hall AJ, Stawell RJ, Santamaria JD. Intraocular lymphoma: a series of 14 patients with clinicopathological features and treatment outcomes. Eye (Lond). 2003;17:513–21.

    Article  CAS  Google Scholar 

  7. Yoo JH, Kim SY, Jung KB, Lee JJ, Lee SJ. Intraocular involvement of a nasal natural killer T-cell lymphoma: a case report. Korean J Ophthalmol. 2012;26:54–7.

    Article  PubMed Central  PubMed  Google Scholar 

  8. Mathai A, Lall A, Jain R, Pathengay A. Systemic non-Hodgkin’s lymphoma masquerading as Vogt–Koyanagi–Harada disease in an HIV-positive patient. Clin Exp Ophthalmol. 2006;34:280–2.

    Article  Google Scholar 

  9. Cimino L, Chan CC, Shen D, Masini L, Ilariucci F, Masetti M, et al. Ocular involvement in nasal natural killer T-cell lymphoma. Int Ophthalmol. 2009;29:275–9.

    Article  PubMed Central  PubMed  Google Scholar 

  10. Coupland SE, Anastassiou G, Bornfeld N, Hummel M, Stein H. Primary intraocular lymphoma of T-cell type: report of a case and review of the literature. Graefe’s Arch Clin Exp Ophthalmol [Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie] 2005;243:189–197.

  11. Hawkes EA, Wotherspoon A, Cunningham D. Diagnosis and management of rare gastrointestinal lymphomas. Leuk Lymphoma. 2012;53:2341–50.

    Article  PubMed  Google Scholar 

  12. Yoshimura N, Tadami T, Kawaguchi T, Sako M, Yoshimoto H, Yamaka T, et al. Processed blood volume impacts clinical efficacy in patients with ulcerative colitis undergoing adsorptive depletion of myeloid lineage leucocytes. J Gastroenterol. 2012;47:49–55.

    Article  PubMed  Google Scholar 

  13. Mani H, Climent F, Colomo L, Pittaluga S, Raffeld M, Jaffe ES. Gall bladder and extrahepatic bile duct lymphomas: clinicopathological observations and biological implications. Am J Surg Pathol. 2010;34:1277–86.

    Article  PubMed Central  PubMed  Google Scholar 

  14. Darmas B, Mahmud S, Abbas A, Baker AL. Is there any justification for the routine histological examination of straightforward cholecystectomy specimens? Ann R Coll Surg Engl. 2007;89:238–41.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  15. Farah SS, Morris P, Dubrava Z, Du Guesclin A, Naqash N. Angioblastic T-cell lymphoma of the gall bladder. ANZ J Surg. 2012;82(10):752–3.

    Article  PubMed  Google Scholar 

  16. Mitropoulos FA, Angelopoulou MK, Siakantaris MP, Rassidakis G, Vayiopoulos GA, Papalampros E, et al. Primary non-Hodgkin’s lymphoma of the gall bladder. Leuk Lymphoma. 2000;40:123–31.

    Article  CAS  PubMed  Google Scholar 

  17. Davis JL, Viciana AL, Ruiz P. Diagnosis of intraocular lymphoma by flow cytometry. Am J Ophthalmol. 1997;124:362–72.

    Article  CAS  PubMed  Google Scholar 

Download references

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Departments of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, No. 1, Shuaifuyuan, Dongcheng District, Beijing, 100730, China

    Yamin Lai, Aiming Yang, Jingnan Li & Jiaming Qian

  2. Departments of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, No. 1, Shuaifuyuan, Dongcheng District, Beijing, 100730, China

    Meifen Zhang & Xiao Zhang

  3. ICU, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, No. 1, Shuaifuyuan, Dongcheng District, Beijing, 100730, China

    Xiang Zhou

  4. Departments of Pathology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, No. 1, Shuaifuyuan, Dongcheng District, Beijing, 100730, China

    Dingrong Zhong

  5. Departments of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, No. 1, Shuaifuyuan, Dongcheng District, Beijing, 100730, China

    Tao Hong

  6. Department of Epidemiology and Biostatistics, Institute of Basic Medicine, Chinese Academy of Medical Science, School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China

    Li Wang

Authors
  1. Yamin Lai
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Meifen Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Li Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Aiming Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jingnan Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Xiao Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Xiang Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Tao Hong
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Jiaming Qian
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Dingrong Zhong
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Jiaming Qian or Dingrong Zhong.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lai, Y., Zhang, M., Wang, L. et al. Uveitis and T cell lymphoma: a rare but notable relationship. Med Oncol 31, 992 (2014). https://doi.org/10.1007/s12032-014-0992-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s12032-014-0992-6

Keywords

Search

Navigation