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Clinical significance of Wnt-11 and squamous cell carcinoma antigen expression in cervical cancer

Medical Oncology volume 31, Article number: 933 (2014) Cite this article

Abstract

The purpose of the study was to determine the expression patterns of Wnt-11 and squamous cell carcinoma antigen in cervical cancer tissues and to explore their clinical significance and correlation with clinicopathological parameters. The expression of Wnt-11 and squamous cell carcinoma antigen was detected in 127 cervical cancer tissues, 21 cervical intraepithelial neoplasia, as well as in 20 healthy controls by immunohistochemistry, and the relationship of Wnt-11 and squamous cell carcinoma antigen expression with clinicopathological parameters was analyzed. Both Wnt-11 and squamous cell carcinoma antigen were more commonly expressed in cervical cancer than in cervical intraepithelial neoplasia and in normal cervical tissue (respectively; P < 0.05); further, Wnt-11 and squamous cell carcinoma antigen expression in cervical cancer were positively correlated (r = 0.271, P < 0.05). In comparing the expression with clinicopathological parameters of tumor samples, Wnt-11 and squamous cell carcinoma antigen were both associated with FIGO stage, lymph node metastasis, and tumor size (P < 0.05), but not with patient age, pathological type, or differentiation. Increased Wnt-11 protein levels in cervical carcinoma samples were associated with a poor outcome in univariate and multivariate analysis. Wnt-11 and squamous cell carcinoma antigen are related to the malignancy degree and metastasis of cervical cancer, and thus may play a coordinating role in the occurrence and progression of cervical cancer. The study indicated that Wnt-11 may be a useful prognostic indicator for cervical carcinoma.

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Acknowledgments

This work was supported by the National Nature Science Foundation of China (Grant No 81372776, Grant No 81202047), the Higher Specialized Research Fund for the Doctoral Program (Grant No 20122104110014), the Science and Technology Program of Liaoning Province (Grant No 2011225009), the Peak Medical Construction Special Project of Liaoning Province (Grant No 2010696), and the Free Researcher Project of Shengjing Hospital (Grant No 201302).

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Authors have no conflicts of interest.

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Affiliations

  1. Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, No. 36 Sanhao St, Heping District, Shenyang, 110004, Liaoning Province, China

    Heng Wei, Ning Wang, Yao Zhang, Shizhuo Wang, Xiaoao Pang, Jing Zhang, Qingshuang Luo & Shulan Zhang

  2. Practical Pharmacy and Clinical Remedies, Shengjing Hospital, China Medical University, No. 36 Sanhao St, Heping District, Shenyang, 110004, Liaoning Province, China

    Youbo Su

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  1. Heng Wei
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  2. Ning Wang
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  3. Yao Zhang
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  4. Shizhuo Wang
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  5. Xiaoao Pang
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  6. Jing Zhang
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  7. Qingshuang Luo
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  8. Youbo Su
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  9. Shulan Zhang
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Correspondence to Shulan Zhang.

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Wei, H., Wang, N., Zhang, Y. et al. Clinical significance of Wnt-11 and squamous cell carcinoma antigen expression in cervical cancer. Med Oncol 31, 933 (2014). https://doi.org/10.1007/s12032-014-0933-4

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  • DOI: https://doi.org/10.1007/s12032-014-0933-4

Keywords

  • Wnt-11
  • Squamous cell carcinoma antigen (SCC-Ag)
  • Cervical cancer
  • Immunohistochemistry