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LRRC4 haplotypes are associated with pituitary adenoma in a Chinese population

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Abstract

Pituitary adenoma results from accumulation of multiple genetic and/or epigenetic aberrations such as GNAS, MEN1, CNC, and FIPA. LRRC4 is relatively tissue-specific expressed gene in the normal brain and downregulated expression in glioma (87.5 %), meningioma (80.9 %), and pituitary adenoma (85.5 %). It has been suggested that the aberrant expression of LRRC4 contributes to tumorigenesis in glioma. However, little is known yet about association between LRRC4 and risk of pituitary adenoma. In this study, we genotyped three LRRC4 haplotype-tagging SNPs (htSNP) by direct sequencing in case–control studies, which included 183 Han Chinese patients diagnosed with pituitary adenoma and 183 age-, gender-matched, and geographically matched Han Chinese controls. Haplotypes were reconstructed according to the genotyping data and linkage disequilibrium status of the htSNP. We observed statistically significant differences regarding the genotype TT + CT of rs6944446 in the NCA. Haplotype AC of rs3823994–rs6944446 is suggested to have a protective effect in the development of pituitary adenoma (OR 0.339; 95 % CI 0.123–0.934). However, haplotype GT of rs3808058–rs6944446 (OR 1.575; 95 % CI 1.048–2.368) and AGT of rs3823994–rs6944446–rs3808058 (OR 1.673; 95 % CI 1.056–2.651) might be a risk factor for pituitary adenoma development. In a brief, the results support the hypothesis that polymorphisms or haplotypes in the LRRC4 may have important research significance and could be used to predict the risk of pituitary adenoma.

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Acknowledgments

This study was supported by grants from the National Science Foundation of China (81101541), the Hunan Province Natural Sciences Foundations of China (11JJ1013), and Specialized Research Fund for the Doctoral Program of Higher Education (20110162120038). We gratefully acknowledge the participation and cooperation of pituitary adenoma patients and individuals without a history of cancer.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Cancer Research Institute, Central South University, Changsha, Hunan, China

    Lan Xiao, Chaofeng Tu, Zhibin Yu, Qianqian Lei, Zeyou Wang, Gang Xu, Minghua Wu & Guiyuan Li

  2. Disease Genome Research Center, Central South University, Changsha, Hunan, China

    Lan Xiao, Chaofeng Tu, Zhibin Yu, Qianqian Lei, Zeyou Wang, Gang Xu, Minghua Wu & Guiyuan Li

  3. Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha, China

    Lan Xiao, Chaofeng Tu, Zhibin Yu, Qianqian Lei, Zeyou Wang, Gang Xu, Minghua Wu & Guiyuan Li

  4. Key Laboratory of Carcinogenesis, Ministry of Health, Changsha, China

    Lan Xiao, Chaofeng Tu, Zhibin Yu, Qianqian Lei, Zeyou Wang, Gang Xu, Minghua Wu & Guiyuan Li

  5. The Center for Skull Base Surgery and Neurooncology, Hunan, China

    Lan Xiao, Zhibin Yu, Qianqian Lei, Zeyou Wang, Gang Xu & Minghua Wu

  6. Affiliated Tumor Hospital, Xiangya Medicine School, Central South University, Changsha, 410003, China

    Shuai Chen

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  1. Lan Xiao
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  2. Chaofeng Tu
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  3. Shuai Chen
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  7. Gang Xu
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  9. Guiyuan Li
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Corresponding author

Correspondence to Minghua Wu.

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Xiao, L., Tu, C., Chen, S. et al. LRRC4 haplotypes are associated with pituitary adenoma in a Chinese population. Med Oncol 31, 888 (2014). https://doi.org/10.1007/s12032-014-0888-5

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  • DOI: https://doi.org/10.1007/s12032-014-0888-5

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