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Outcomes of peripheral blood stem cell transplantation patients from HLA-mismatched unrelated donor with antithymocyte globulin (ATG)-Thymoglobulin versus ATG-Fresenius: a single-center study

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Abstract

Although antithymocyte globulin (ATG) had been widely used in hematopoietic stem cell transplantation from unrelated donor due to its ability to prevent acute and chronic graft-versus-host disease (GVHD), the comparative efficacy and safety of ATG-Thymoglobulin (ATG-T) and ATG-Fresenius (ATG-F) in patients undergoing HLA-mismatched allogeneic peripheral blood stem cell transplantation from unrelated donors (UR-PBSCT) has not been evaluated. Retrospective analysis of patients who underwent HLA-mismatched UR-PBSCT between January 2003 and December 2013 and received pre-transplant ATG-T at a total dose of 10 mg/kg or ATG-F at a total dose of 20 mg/kg was performed. Patients who received ATG-T (n = 23) or ATG-F (n = 28) had similar baseline demographic, disease, and transplant characteristics. There were no significant between-groups differences in the probability of acute GVHD (P = 0.721) and chronic GVHD (P = 0.439). ATG-F was associated with nonsignificant trends toward higher disease-free survival at 3-year follow-up compared with ATG-T (45.7 ± 11.1 vs 61.3 ± 9.7 %, respectively, P = 0.07). A significantly greater proportion of ATG-T patients experienced high fever than ATG-F patients (P < 0.01) during ATG infusion. There was no difference in the rate of infection between the two treatment groups. There were less adverse effects comparing ATG-F with ATG-T. ATG-T at a total dose of 10 mg/kg and ATG-F at a total dose of 20 mg/kg had a similar clinical outcome in the setting of HLA-mismatched UR-PBSCT.

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Acknowledgments

The authors wish to acknowledge all the physicians, nurses, and supporting personnel for their dedicated care of patients in this study. This study was supported by the Capital Health Research and Development of Special (No. 2011-5001-07).

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The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Hematology and BMT, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China

    Wenrong Huang, Xiaoli Zhao, Yamin Tian, Tingting Cao, Yanfen Li, Zhanxiang Liu, Yu Jing, Shuhong Wang, Chunji Gao & Li Yu

  2. Department of Hematology, Hainan Branch of Chinese PLA General Hospital, Linwang Street, Sanya City, 572013, Hainan Province, China

    Wenrong Huang & Chunji Gao

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  1. Wenrong Huang
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  2. Xiaoli Zhao
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Correspondence to Wenrong Huang.

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Huang, W., Zhao, X., Tian, Y. et al. Outcomes of peripheral blood stem cell transplantation patients from HLA-mismatched unrelated donor with antithymocyte globulin (ATG)-Thymoglobulin versus ATG-Fresenius: a single-center study. Med Oncol 32, 32 (2015). https://doi.org/10.1007/s12032-014-0465-y

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