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Dietary fiber intake and risk of renal cell carcinoma: evidence from a meta-analysis

Medical Oncology volume 31, Article number: 125 (2014) Cite this article

Abstract

The aim of this study was to investigate the possible relationships between dietary fiber intake and risk of renal cell carcinoma (RCC). Electronic databases including MEDLINE, EMBASE and Web of Science were searched to find eligible studies. Random-effects relative risk (RR) and its corresponding 95 % confidence interval (CI) were used. Besides, random-effects dose–response analyses were also performed to clarify the dose–response relations. Finally, publication bias was assessed by Egger’s test and Begg’s test. All p values were two tailed. Seven studies, including two cohort studies and five case–control studies, were eligible and included in this meta-analysis. Overall analysis in highest versus lowest level revealed that total dietary fiber intake was associated with reduced RCC risk (RR 0.84, 95 % CI 0.74–0.96). In addition, pooled estimated data showed that risk of RCC was significantly associated with vegetable and legume fiber intake (RR 0.70, RR 0.80, respectively), but not with fruit and cereal fiber intake (RR 0.92, RR 1.04, respectively). However, in dose–response analysis, no significant association was reported. Finally, no publication bias was detected by Egger’s or Begg’s test. The dietary fiber intake, especially vegetable and legume fiber, may be associated with reduced RCC risk. Considering the limitations of the included studies, more well-designed prospective studies will be needed to confirm our findings.

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Acknowledgments

Tian-bao Huang, Pei-pei Ding, Jian-feng Cheng, Xu-dong Yao and Huan Liu were responsible for the initial plan, data collection, statistic analysis and for conducting the study. Tian-bao Huang, Long Zhang, Yang Yan, Peng-cheng Liu and Jun-hua Zheng contributed to data collection, data extraction, data interpretation and manuscript drafting. Xu-dong Yao was the guarantor for this paper and has full responsibility for this study. Besides, we thank Lu Feng for manuscript proofreading.

Conflict of interest

Author’s disclosures of potential conflicts of interest: none for all authors.

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Affiliations

  1. Department of Urology, Shanghai Tenth People’s Hospital, Tongji University, 301 Yanchang Road, Shanghai, 200072, China

    Tian-bao Huang, Yang Yan, Huan Liu, Peng-cheng Liu, Jian-ping Che, Jun-hua Zheng & Xu-dong Yao

  2. Department of First Clinical Medical College, Nanjing Medical University, Nanjing, Jiangsu, China

    Tian-bao Huang, Huan Liu, Peng-cheng Liu & Jun-hua Zheng

  3. Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China

    Pei-pei Ding, Jian-feng Chen & Long Zhang

  4. Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, 200032, China

    Pei-pei Ding, Jian-feng Chen & Long Zhang

  5. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China

    Pei-pei Ding, Jian-feng Chen & Long Zhang

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  1. Tian-bao Huang
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Correspondence to Xu-dong Yao.

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Tian-bao Huang and Pei-pei Ding have contributed equally to this work.

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Huang, Tb., Ding, Pp., Chen, Jf. et al. Dietary fiber intake and risk of renal cell carcinoma: evidence from a meta-analysis. Med Oncol 31, 125 (2014). https://doi.org/10.1007/s12032-014-0125-2

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  • DOI: https://doi.org/10.1007/s12032-014-0125-2

Keywords

  • Renal cell carcinoma
  • Dietary fiber
  • Meta-analysis