Skip to main content

Advertisement

SpringerLink
Log in

Genetic polymorphisms of TERT and CLPTM1L, cooking oil fume exposure, and risk of lung cancer: a case–control study in a Chinese non-smoking female population

  • Original Paper
  • Published:
Medical Oncology Aims and scope Submit manuscript

Abstract

Genetic polymorphisms of telomerase reverse transcriptase (TERT) and cleft lip and palate transmembrane 1-like (CLPTM1L) genes in chromosome 5p15.33 region were previously identified to influence the risks of lung cancer. This study aimed to investigate the association between polymorphisms in TERT and CLPTM1L genes with the risk of lung cancer, as well as the interaction of the polymorphisms and the environmental risk factors in Chinese non-smoking females. A hospital-based case–control study of 524 cases and 524 controls was conducted. Two polymorphisms were determined by Taqman allelic discrimination method. The statistical analyses were performed mostly with SPSS. This study showed that the individuals with the TG or GG genotypes of TERT polymorphism (rs2736100) were at an increased risk for lung cancer compared with those carrying the TT genotype in Chinese non-smoking females [adjusted odds ratios (ORs) were 1.44 and 1.85, 95 % confidence intervals (CIs) were 1.09–1.90 and 1.29–2.65, respectively]. The stratified analysis suggested that increased risks were more pronounced in lung adenocarcinoma (corresponding ORs were 1.71 and 2.30, 95 % CIs were 1.25–2.35 and 1.54–3.43). Our results showed that exposure to cooking oil fume was associated with increased risk of lung cancer in Chinese non-smoking females (adjusted ORs 1.59, 95 % CI 1.13–2.23). However, we did not observe a significant interaction of cooking oil fume and TERT polymorphism on lung cancer among Chinese non-smoking females. TERT polymorphism (rs2736100) might be a genetic susceptibility factor for lung cancer in non-smoking females in China.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008. GLOBOCAN 2008. Int J Cancer. 2010;2010(127):2893–917.

    Article  Google Scholar 

  2. Payne S, Chan N, Davies A, Poon E, Connor S, Goh C. Supportive, palliative, and end-of-life care for patients with cancer in Asia: resource-stratified guidelines from the Asian Oncology Summit 2012. Lancet Oncol. 2012;13:e492–500.

    Article  PubMed  Google Scholar 

  3. Chen W, Zheng R, Zhang S, Zhao P, Li G, Lingyou W, He J. Report of incidence and mortality in China cancer registries, 2009. Chin J Cancer Res. 2013;25:10–21.

    CAS  PubMed Central  PubMed  Google Scholar 

  4. Couraud S, Zalcman G, Milleron B, Morin F, Souquet P-J. Lung cancer in never smokers—a review. Eur J Cancer. 2012;48:1299–311.

    Article  CAS  PubMed  Google Scholar 

  5. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55:74–108.

    Article  PubMed  Google Scholar 

  6. Clément-Duchêne C, Wakelee H. Lung cancer incidence in never smokers. EJCMO. 2010;2:49–57.

    Google Scholar 

  7. McKay JD, Hung RJ, Gaborieau V, Boffetta P, Chabrier A, Byrnes G, et al. Lung cancer susceptibility locus at 5p15.33. Nat Genet. 2008;40:1404–6.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  8. Rafnar T, Sulem P, Stacey SN, Geller F, Gudmundsson J, Sigurdsson A, et al. Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Nat Genet. 2009;41:221–7.

    Article  CAS  PubMed  Google Scholar 

  9. Wang Y, Broderick P, Matakidou A, Eisen T, Houlston RS. Role of 5p15.33 (TERTCLPTM1L),6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers. Carcinogenesis. 2010;31:234–8.

    Article  PubMed  Google Scholar 

  10. Rothman K. Modern epidemiology. Boston, Toronto: Little, Brown and Company; 1986.

    Google Scholar 

  11. Young NS. Telomere biology and telomere diseases: implications for practice and research. Hematology Am Soc Hematol Educ Program. 2010;2010:30–5.

    Article  PubMed  Google Scholar 

  12. Rodier F, Kim SH, Nijjar T, Yaswen P, Campisi J. Cancer and aging: the importance of telomeres in genome maintenance. Int J Biochem Cell Biol. 2005;37:977–90.

    Article  CAS  PubMed  Google Scholar 

  13. Lantuejoul S, Salon C, Soria JC, Brambilla E. Telomerase expression in lung preneoplasia and neoplasia. Int J Cancer. 2007;120:1835–41.

    Article  CAS  PubMed  Google Scholar 

  14. Wyatt HD, West SC, Beattie TL. InTERTpreting telomerase structure and function. Nucleic Acids Res. 2010;38:5609–22.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  15. Fernandez-Garcia I, Ortiz-de-Solorzano C, Montuenga LM. Telomeres and telomerase in lung cancer. J Thorac Oncol. 2008;3:1085–8.

    Article  PubMed  Google Scholar 

  16. Blanco D, Vicent S, Fraga MF, Fernandez-Garcia I, Freire J, Lujambio A, et al. Molecular analysis of a multistep lung cancer model induced by chronic inflammation reveals epigenetic regulation of p16 and activation of the DNA damage response pathway. Neoplasia. 2007;9:840–52.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  17. Cha N, Li XY, Zhao YJ, Wang EH, Wu GP. hTERT gene amplification and clinical significance in pleural effusions of patients with lung cancer. Clin Lung Cancer. 2012;13:494–9.

    Article  CAS  PubMed  Google Scholar 

  18. Landi MT, Chatterjee N, Yu K, Goldin LR, Goldstein AM, Rotunno M, et al. A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Am J Hum Genet. 2009;85:679–91.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  19. Lan Q, Cawthon R, Gao Y, Hu W, Hosgood HD 3rd, Barone-Adesi F, et al. Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China. PLoS ONE. 2013;8:e59230.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  20. Zhao Z, Li C, Yang L, Zhang X, Zhao X, Song X, et al. Significant association of 5p15.33 (TERT-CLPTM1L genes) with lung cancer in Chinese Han population. Exp Lung Res. 2013;39:91–8.

    Article  CAS  PubMed  Google Scholar 

  21. Hu Z, Wu C, Shi Y, Guo H, Zhao X, Yin Z, et al. A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat Genet. 2011;43:792–6.

    Article  CAS  PubMed  Google Scholar 

  22. Jin G, Xu L, Shu Y, Tian T, Liang J, Xu Y, et al. Common genetic variants on 5p15.33 contribute to risk of lung adenocarcinoma in a Chinese population. Carcinogenesis. 2009;30:987–90.

    Article  CAS  PubMed  Google Scholar 

  23. Truong T, Hung RJ, Amos CI, Wu X, Bickeboller H, Rosenberger A, et al. Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium. J Natl Cancer Inst. 2010;102:959–71.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  24. Li M, Yin Z, Guan P, Li X, Cui Z, Zhang J, Bai W, He Q, Zhou B. XRCC1 polymorphisms, cooking oil fume and lung cancer in Chinese women nonsmokers. Lung Cancer. 2008;62:145–51.

    Article  PubMed  Google Scholar 

  25. Yin Z, Su M, Li X, Li M, Ma R, He Q, Zhou B. ERCC2, ERCC1 polymorphisms and haplotypes, cooking oil fume and lung adenocarcinoma risk in Chinese non-smoking females. J Exp Clin Cancer Res. 2009;28:153.

    Article  PubMed Central  PubMed  Google Scholar 

  26. Wu C, Zhang Z, Li D. Experimental study on DNA damages induced by cooking oil fume condensates. J China Public Health. 2002;18:137–8 (Chinese).

    CAS  Google Scholar 

  27. Zhang H, Wang G, Tan W. Study on the effects of cooking oil fume condensate on the DNA integrality. Wei Sheng Yan Jiu. 2002;31:238–40 (Chinese).

    CAS  PubMed  Google Scholar 

  28. Tung YH, Ko JL, Liang YF, Yin L, Pu Y, Lin P. Cooking oil fume induced cytokine expression and oxidative stress in human lung epithelial cells. Environ Res. 2001;87:47–54.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

We are grateful to patients for their participation. We would like to thank all the personnel at the hospitals in our study. This study was supported by National Nature Science Foundation of China Grant 81102194.

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Epidemiology, School of Public Health, China Medical University, Shenyang, 110001, People’s Republic of China

    Zhihua Yin, Yangwu Ren, Qianqian Wang & Baosen Zhou

  2. Key Laboratory of Cancer Etiology and Intervention (China Medical University), Liaoning Provincial Department of Education, Liaoning, People’s Republic of China

    Zhihua Yin, Yangwu Ren, Qianqian Wang & Baosen Zhou

  3. China Medical University, Shenyang, 110001, China

    Zhigang Cui & Qincheng He

  4. Department of Radiotherapy, Shenyang Northern Hospital, Shenyang, 110001, People’s Republic of China

    Haibo Zhang & Ying Yan

  5. Department of Radiation Oncology, Fourth Affiliated Hospital of China Medical University, Shenyang, 110001, People’s Republic of China

    Yuxia Zhao

  6. Department of Internal Medicine, Liaoning Cancer Hospital & Institute, Shenyang, 110001, People’s Republic of China

    Rui Ma

Authors
  1. Zhihua Yin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zhigang Cui
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yangwu Ren
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Haibo Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ying Yan
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yuxia Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Rui Ma
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Qianqian Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Qincheng He
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Baosen Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Baosen Zhou.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yin, Z., Cui, Z., Ren, Y. et al. Genetic polymorphisms of TERT and CLPTM1L, cooking oil fume exposure, and risk of lung cancer: a case–control study in a Chinese non-smoking female population. Med Oncol 31, 114 (2014). https://doi.org/10.1007/s12032-014-0114-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s12032-014-0114-5

Keywords

Search

Navigation