Medical Oncology

, 31:56 | Cite as

Increased CD59 protein expression is associated with the outcome of patients with diffuse large B-cell lymphoma treated with R-CHOP

  • Guoqi Song
  • William C. Cho
  • Ling Gu
  • Bangshun He
  • Yuqin Pan
  • Shukui WangEmail author
Original Paper


The objective was to investigate the expression and prognostic value of CD59 expression in patients with diffuse large B-cell lymphoma (DLBCL) who underwent rituximab-cyclophosphamide, adriamycin, vincristine, and prednisone (R-CHOP). The immunohistochemical expressions of CD59 in 186 well-characterized DLBCL patients were evaluated using tissue microarrays and then were related to known tumor- and patient-related variables and to survival. The results show that CD59 expressions were not statistically different between the germinal center B-cell-like-type and the activated B-cell-like-type. We also analyzed the relationships of CD59 expression with overall survival (OS) and progression-free survival (PFS) in DLBCL patients who were uniformly treated with R-CHOP. The high expression of CD59 was correlated with poor OS and PFS compared with the low-expression CD59. Our findings indicate that the CD59 level at onset is an independent predictor of the prognosis of DLBCL patients treated with R-CHOP.


Diffuse large B-cell lymphoma (DLBCL) CD59 R-CHOP 


Conflict of interest

The author(s) confirm that this article content has no conflict of interest.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Guoqi Song
    • 1
  • William C. Cho
    • 2
  • Ling Gu
    • 3
  • Bangshun He
    • 3
  • Yuqin Pan
    • 3
  • Shukui Wang
    • 1
    Email author
  1. 1.Medical School of Southeast UniversityNanjingChina
  2. 2.Department of Clinical OncologyQueen Elizabeth Hospital, Hong KongKowloonHong Kong
  3. 3.Central Laboratory of Nanjing First HospitalNanjing Medical UniversityNanjingChina

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