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Safety and efficacy of second-line treatment with folinic acid, 5-fluorouracil and irinotecan (FOLFIRI) in combination of panitumumab and bevacizumab for patients with metastatic colorectal cancer

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Abstract

We investigated the efficacy and safety of a new second-line chemotherapy of combining folinic acid, 5-fluorouracil and irinotecan (FOLFIRI) with both panitumumab and bevacizumab to treat patients with metastatic colorectal cancer (mCRC). Patients with mCRC and unsuccessful previous oxaliplatin-based chemotherapy were included in the study. The FOLFIRI arm was given FOLFIRI only. The FOLFIRI+PB arm was given panitumumab (3 mg/kg) and bevacizumab (3 mg/kg) plus FOLFIRI every other week. Between 2009 and 2013, 155 and 137 patients were included in the FOLFIRI arm and FOLFIRI+PB arm, respectively. The response rate was 40.1 % for FOLFIRI+PB arm versus 30.1 % for FOLFIRI arm. The disease-controlled rate in FOLFIRI+PB arm was improved to 62.2 from 50.2 % in FOLFIRI arm. The median overall survival was 13.9 months in FOLFIRI+PB arm as compared to 10.7 months in FOLFIRI arm. A series of adverse events were comparable between two arms, whereas some of the antibody therapy-associated toxicities were observed in FOLFIRI+PB arm. The new strategy of combining panitumumab and bevacizumab with FOLFIRI as second-line chemotherapy for patients with mCRC is safe and feasible.

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Authors and Affiliations

  1. Department of General Surgery, Zhejiang Xiaoshan Hospital, 728 North Yucai Road, Xiaoshan District, Hangzhou, 311202, Zhejiang, China

    Song Xie, Zhikun Fan, Lifeng He, Wenbing Xu & Zhen Qin

  2. Department of Radiation Oncology, Zhejiang Xiaoshan Hospital, 728 North Yucai Road, Xiaoshan District, Hangzhou, 311202, Zhejiang, China

    Guoping Han

  3. Department of Pediatrics, The First Affiliated Hospital of College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China

    Zhen Qin

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  1. Song Xie
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  2. Guoping Han
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  3. Zhikun Fan
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  4. Lifeng He
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  5. Wenbing Xu
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Correspondence to Zhen Qin.

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Xie, S., Han, G., Fan, Z. et al. Safety and efficacy of second-line treatment with folinic acid, 5-fluorouracil and irinotecan (FOLFIRI) in combination of panitumumab and bevacizumab for patients with metastatic colorectal cancer. Med Oncol 31, 35 (2014). https://doi.org/10.1007/s12032-014-0035-3

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  • DOI: https://doi.org/10.1007/s12032-014-0035-3

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