Skip to main content

Association analysis between MDR1 genetic variant and breast cancer risk factors in Chinese Han population

Medical Oncology volume 30, Article number: 683 (2013) Cite this article

Abstract

The multidrug resistance 1 gene (MDR1) is an important candidate gene for influencing breast cancer susceptibility. This study aimed to evaluate the association between MDR1 genetic variants and breast cancer susceptibility. A total of 340 breast cancer patients and 348 cancer-free controls were enrolled in this study. The patients’ general characteristics and related risk factors of breast cancer were collected by questionnaires. The c.4125A>C genetic variant was genotyped through created restriction site polymerase chain reaction method. Our data suggest that there are no significant differences in the allelic and genotypic frequencies between breast cancer patients and cancer-free controls. Moreover, the distribution of breast cancer patients’ risk factors is not different among AA, AC, and CC genotypes. These preliminary results suggest that the c.4125A>C genetic variant is not significantly associated with breast cancer susceptibility.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

References

  1. Aapro MS. Adjuvant therapy of primary breast cancer: a review of key findings from the 7th international conference, St. Gallen, February 2001. Oncologist. 2001;6:376–85.

    PubMed  Article  CAS  Google Scholar 

  2. Mousavi SM, Montazeri A, Mohagheghi MA, Jarrahi AM, Harirchi I, Najafi M, Ebrahimi M. Breast cancer in Iran: an epidemiological review. Breast J. 2007;13:383–91.

    PubMed  Article  Google Scholar 

  3. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127:2893–917.

    PubMed  Article  CAS  Google Scholar 

  4. Kusinska R, Gorniak P, Pastorczak A, Fendler W, Potemski P, Mlynarski W, Kordek R. Influence of genomic variation in FTO at 16q12.2, MC4R at 18q22 and NRXN3 at 14q31 genes on breast cancer risk. Mol Biol Rep. 2012;39:2915–9.

    PubMed  Article  CAS  Google Scholar 

  5. Chen G, Quan S, Hu Q, Wang L, Xia X, Wu J. Lack of association between MDR1 C3435T polymorphism and chemotherapy response in advanced breast cancer patients: evidence from current studies. Mol Biol Rep. 2012;39:5161–8.

    PubMed  Article  CAS  Google Scholar 

  6. Fan L, Zheng Y, Yu KD, Liu GY, Wu J, Lu JS, Shen KW, Shen ZZ, Shao ZM. Breast cancer in a transitional society over 18 years: trends and present status in Shanghai, China. Breast Cancer Res Treat. 2009;117:409–16.

    PubMed  Article  Google Scholar 

  7. Lohrisch C, Piccart M. An overview of HER2. Semin Oncol. 2001;28:3–11.

    PubMed  Article  CAS  Google Scholar 

  8. Larkin A, O’Driscoll L, Kennedy S, Purcell R, Moran E, Crown J, Parkinson M, Clynes M. Investigation of MRP-1 protein and MDR-1 P-glycoprotein expression in invasive breast cancer: a prognostic study. Int J Cancer. 2004;112:286–94.

    PubMed  Article  CAS  Google Scholar 

  9. Hoffmann J, Sommer A. Steroid hormone receptors as targets for the therapy of breast and prostate cancer—recent advances, mechanisms of resistance, and new approaches. J Steroid Biochem Mol Biol. 2005;93:191–200.

    PubMed  Article  CAS  Google Scholar 

  10. Turgut S, Yaren A, Kursunluoglu R, Turgut G. MDR1 C3435T polymorphism in patients with breast cancer. Arch Med Res. 2007;38:539–44.

    PubMed  Article  CAS  Google Scholar 

  11. Tatari F, Salek R, Mosaffa F, Khedri A, Behravan J. Association of C3435T single-nucleotide polymorphism of MDR1 gene with breast cancer in an Iranian population. DNA Cell Biol. 2009;28:259–63.

    PubMed  Article  CAS  Google Scholar 

  12. Hussien YM, Gharib AF, Awad HA, Karam RA, Elsawy WH. Impact of DNA repair genes polymorphism (XPD and XRCC1) on the risk of breast cancer in Egyptian female patients. Mol Biol Rep. 2012;39:1895–901.

    PubMed  Article  CAS  Google Scholar 

  13. Fang Y, Zhao Q, Ma G, Han Y, Lou N. Investigation on MDR1 gene polymorphisms and its relationship with breast cancer risk factors in Chinese women. Med Oncol. 2013;30:375.

    PubMed  Article  Google Scholar 

  14. Wang F, Fang Q, Ge Z, Yu N, Xu S, Fan X. Common BRCA1 and BRCA2 mutations in breast cancer families: a meta-analysis from systematic review. Mol Biol Rep. 2012;39:2109–18.

    PubMed  Article  CAS  Google Scholar 

  15. Yuan ZR, Li JY, Li J, Zhang LP, Gao X, Gao HJ, Xu SZ. Investigation on BRCA1 SNPs and its effects on mastitis in Chinese commercial cattle. Gene. 2012;505:190–4.

    PubMed  Article  CAS  Google Scholar 

  16. Gervasini G, Carrillo JA, Garcia M, San Jose C, Cabanillas A, Benitez J. Adenosine triphosphate-binding cassette B1 (ABCB1) (multidrug resistance 1) G2677T/A gene polymorphism is associated with high risk of lung cancer. Cancer. 2006;107:2850–7.

    PubMed  Article  CAS  Google Scholar 

  17. Bodor M, Kelly EJ, Ho RJ. Characterization of the human MDR1 gene. AAPS J. 2005;7:E1–5.

    PubMed  Article  Google Scholar 

  18. Borst P, Elferink RO. Mammalian ABC transporters in health and disease. Annu Rev Biochem. 2002;71:537–92.

    PubMed  Article  CAS  Google Scholar 

  19. Cizmarikova M, Wagnerova M, Schonova L, Habalova V, Kohut A, Linkova A, Sarissky M, Mojzis J, Mirossay L, Mirossay A. MDR1 (C3435T) polymorphism: relation to the risk of breast cancer and therapeutic outcome. Pharmacogenomics J. 2010;10:62–9.

    PubMed  Article  CAS  Google Scholar 

  20. Jamroziak K, Mlynarski W, Balcerczak E, Mistygacz M, Trelinska J, Mirowski M, Bodalski J, Robak T. Functional C3435T polymorphism of MDR1 gene: an impact on genetic susceptibility and clinical outcome of childhood acute lymphoblastic leukemia. Eur J Haematol. 2004;72:314–21.

    PubMed  Article  CAS  Google Scholar 

  21. George J, Dharanipragada K, Krishnamachari S, Chandrasekaran A, Sam SS, Sunder E. A single-nucleotide polymorphism in the MDR1 gene as a predictor of response to neoadjuvant chemotherapy in breast cancer. Clin Breast Cancer. 2009;9:161–5.

    PubMed  Article  CAS  Google Scholar 

  22. Hoffmeyer S, Burk O, von Richter O, Arnold HP, Brockmoller J, Johne A, Cascorbi I, Gerloff T, Roots I, Eichelbaum M, Brinkmann U. Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci USA. 2000;97:3473–8.

    PubMed  Article  CAS  Google Scholar 

  23. Kimchi-Sarfaty C, Oh JM, Kim IW, Sauna ZE, Calcagno AM, Ambudkar SV, Gottesman MM. A “silent” polymorphism in the MDR1 gene changes substrate specificity. Science. 2007;315:525–8.

    PubMed  Article  CAS  Google Scholar 

  24. Ambrosone CB, Moysich KB, Furberg H, Freudenheim JL, Bowman ED, Ahmed S, Graham S, Vena JE, Shields PG. CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors. Breast Cancer Res. 2003;5:R45–51.

    PubMed  Article  CAS  Google Scholar 

  25. Chang JH, Gertig DM, Chen X, Dite GS, Jenkins MA, Milne RL, Southey MC, McCredie MR, Giles GG, Chenevix-Trench G, Hopper JL, Spurdle AB. CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors: Australian Breast Cancer Family Study. Breast Cancer Res. 2005;7:R513–21.

    PubMed  Article  CAS  Google Scholar 

  26. Shin MH, Lee KM, Yang JH, Nam SJ, Kim JW, Yoo KY, Park SK, Noh DY, Ahn SH, Kim B, Kang D. Genetic polymorphism of CYP17 and breast cancer risk in Korean women. Exp Mol Med. 2005;37:11–7.

    PubMed  Article  CAS  Google Scholar 

  27. Yuan ZR, Li JY, Li J, Gao X, Xu SZ. Effects of DGAT1 gene on meat and carcass fatness quality in Chinese commercial cattle. Mol Biol Rep. 2013;40:1947–54.

    PubMed  Article  CAS  Google Scholar 

  28. Yuan ZR, Li J, Li JY, Gao X, Xu SZ. SNPs identification and its correlation analysis with milk somatic cell score in bovine MBL1 gene. Mol Biol Rep. 2013;40:7–12.

    PubMed  Article  CAS  Google Scholar 

  29. Sheng X, Zhang L, Tong N, Luo D, Wang M, Xu M, Zhang Z. MDR1 C3435T polymorphism and cancer risk: a meta-analysis based on 39 case–control studies. Mol Biol Rep. 2012;39:7237–49.

    PubMed  Article  CAS  Google Scholar 

  30. Wang J, Wang B, Bi J, Li K, Di J. MDR1 gene C3435T polymorphism and cancer risk: a meta-analysis of 34 case–control studies. J Cancer Res Clin Oncol. 2012;138:979–89.

    PubMed  Article  CAS  Google Scholar 

Download references

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Affiliations

  1. Department of Oncology, The Chinese PLA General Hospital, No. 28, Fuxing Street, Haidian District, Beijing, 100853, People’s Republic of China

    Yi Hu, Jingliang Wang, Haitao Tao, Huan Wang, Xin Zhang, Yao Cheng & Ruixin Li

Authors
  1. Yi Hu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jingliang Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Haitao Tao
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Huan Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Xin Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yao Cheng
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Ruixin Li
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yi Hu.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Hu, Y., Wang, J., Tao, H. et al. Association analysis between MDR1 genetic variant and breast cancer risk factors in Chinese Han population. Med Oncol 30, 683 (2013). https://doi.org/10.1007/s12032-013-0683-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s12032-013-0683-8

Keywords

  • Breast cancer
  • Cancer susceptibility
  • MDR1 gene
  • Genetic variants