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Association between single genetic polymorphisms of MDR1 gene and gastric cancer susceptibility in Chinese

Medical Oncology volume 30, Article number: 643 (2013) Cite this article

Abstract

Gastric cancer is a common cancer worldwide. The multidrug resistance 1 gene (MDR1) is one of the most important candidate genes for influencing gastric cancer susceptibility. This study aimed to analyze the association between genetic variants of MDR1 gene and the susceptibility to gastric cancer in Chinese Han population. A total of 365 gastric cancer patients and 367 cancer-free controls were enrolled in this study. The single genetic polymorphisms (SNPs) of MDR1 gene were genotyped by the created restriction site-polymerase chain reaction method. Our data suggested that the allele and genotype frequencies of c.159G > T and c.1564A > T were statistically different between gastric cancer patients and cancer-free controls. Association analyses indicated that these two SNPs were statistically associated with the increased risk of gastric cancer (for c.159G > T, TT versus (vs.) GG: OR 2.34, 95 % CI 1.31–4.19; TT vs. GT/GG: OR 2.32, 95 % CI 1.32–4.08; T vs. G: OR 1.27, 95 % CI 1.01–1.59; for c.1564A > T, TT vs. AA: OR 2.27, 95 % CI 1.31–3.93; TT vs. AT/AA: OR 2.21, 95 % CI 1.30–3.75; T vs. A: OR 1.30, 95 % CI 1.04–1.62). The allele-T of both these two SNPs may contribute to the susceptibility to gastric cancer in Chinese Han population. The c.159G > T and c.1564A > T genetic variants might be used as molecular markers for detecting gastric cancer susceptibility.

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Affiliations

  1. Department of Gastroenterology, The First Affiliated Hospital, Medical School of Xi’an Jiaotong University, No. 277 Yanta West Road, Xi’an, 710061, Shaanxi Province, People’s Republic of China

    Wen Qiao, Tao Wang, Li Zhang, Qing Tang, Dan Wang & Hongkun Sun

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  1. Wen Qiao
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  2. Tao Wang
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  3. Li Zhang
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  4. Qing Tang
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  5. Dan Wang
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Correspondence to Wen Qiao.

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Qiao, W., Wang, T., Zhang, L. et al. Association between single genetic polymorphisms of MDR1 gene and gastric cancer susceptibility in Chinese. Med Oncol 30, 643 (2013). https://doi.org/10.1007/s12032-013-0643-3

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  • DOI: https://doi.org/10.1007/s12032-013-0643-3

Keywords

  • Gastric cancer
  • MDR1 gene
  • Single nucleotide polymorphisms
  • Susceptibility