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Decreased Kruppel-like factor 4 (KLF4) expression may correlate with poor survival in gastric adenocarcinoma

Medical Oncology volume 30, Article number: 632 (2013) Cite this article

Abstract

Kruppel-like factors (KLFs) play either anti- or pro-proliferation roles in different human cancers. Here, we investigated the expression of KLF4 in gastric cancers and its correlation with clinicopathological parameters and overall survival. KLF4 expression was measured in 118 surgical specimens by immunohistochemical microarray assay. No association of cytoplasmic KLF4 expression with gender, TNM status, stage, survival, and pathological type was found. Using Kaplan–Meier analysis, significantly higher overall survival rate was observed in patients with high cytoplasmic KLF4 expression compared to low cytoplasmic KLF4 expression. Univariate analysis revealed that cytoplasmic KLF4 expression, grade, histological type, lymph node metastasis, and stages were correlated to longer overall survival. Our results suggest that KLF4 may play an anti-oncogenic role in gastric tumorigenesis.

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Acknowledgments

This work was supported by Grant: 99-CCH-IRP-09 from Changhua Christian Hospital.

Conflict of interests

We declare that we did not have conflict of interest.

Author information

Affiliations

  1. Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung, Taiwan

    Li-Sung Hsu

  2. Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan

    Li-Sung Hsu

  3. Department of General Surgery, Changhua Christian Hospital, Changhua, Taiwan

    Chien-Pin Chan

  4. Department of Pathology, Changhua Christian Hospital, 135, Nan-Hsiao Street, Changhua, Taiwan

    Chih-Jung Chen, Shu-Hui Lin & Kun-Tu Yeh

  5. Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan

    Chih-Jung Chen & Shu-Hui Lin

  6. Department of Pathology, School of Medicine, Chung Shan Medical University, Taichung, Taiwan

    Ming-Tsung Lai, Jeng-Dong Hsu & Kun-Tu Yeh

  7. Department of Pathology, Chung Shan Medical University Hospital, Taichung, Taiwan

    Ming-Tsung Lai & Jeng-Dong Hsu

  8. Department of Gastroenterology, Changhua Christian Hospital, Changhua, Taiwan

    Maw-Soan Soon

  9. Graduate Institute of Biotechnology, National Changhua University of Education, Changhua, Taiwan

    Maw-Soan Soon

  10. General Education Center, Chienkuo Technology University, Changhua, Taiwan

    Maw-Soan Soon

Authors
  1. Li-Sung Hsu
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  2. Chien-Pin Chan
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  4. Shu-Hui Lin
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  5. Ming-Tsung Lai
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  6. Jeng-Dong Hsu
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  7. Kun-Tu Yeh
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Corresponding authors

Correspondence to Kun-Tu Yeh or Maw-Soan Soon.

Additional information

Li-Sung Hsu and Chien-Pin Chan contributed equally to this work as first author.

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Hsu, LS., Chan, CP., Chen, CJ. et al. Decreased Kruppel-like factor 4 (KLF4) expression may correlate with poor survival in gastric adenocarcinoma. Med Oncol 30, 632 (2013). https://doi.org/10.1007/s12032-013-0632-6

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  • DOI: https://doi.org/10.1007/s12032-013-0632-6

Keywords

  • Kruppel-like factor 4
  • Gastric adenocarcinoma
  • Immunohistochemical stain