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Thrombotic microangiopathy during docetaxel, trastuzumab, and carboplatin chemotherapy for early-stage HER2+ breast cancer: a case report

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Abstract

Chemotherapy-induced thrombotic microangiopathy is a severe illness that has occurred in a small number of patients treated with carboplatin and combination of docetaxel and trastuzumab chemotherapy. We describe herein the case of a patient with stage IIB breast cancer who developed thrombotic microangiopathy after five cycles of carboplatin, docetaxel, and trastuzumab.

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References

  1. Pisoni R, Ruggenenti P, Remuzzi G. Drug-induced thrombotic microangiopathy; incidence, prevention, and management. Drug Saf. 2001;24(7):491–501.

    Article  PubMed  CAS  Google Scholar 

  2. Symmers W. Thrombotic microangiopathic haemolytic anaemia (thrombotic microangiopathy). Br Med J. 1952;2:897–903.

    Article  PubMed  CAS  Google Scholar 

  3. Siau K, Varughese M. Thrombotic microangiopathy following docetaxel and trastuzumab chemotherapy: a case report. Med Oncol. 2010;27:1057–9.

    Article  PubMed  Google Scholar 

  4. Murgo AJ. Cancer- and chemotherapy-associated thrombotic microangiopathy. In: Kaplan BS, Trompeter RS, Moake JL, editors. Hemolytic-uremic syndrome and thrombotic thrombocytopenic purpura, (kidney disease S v. 10), vol. 22. New York: Marcel Dekker Ltd; 1992. p. 271–95.

    Google Scholar 

  5. Rahdi M, Carpenter SL. Thrombotic microangiopathies. ISRN Hematol. 2012.

  6. Moake JL. Thrombotic microangiopathies. NEJM. 2002;347(8):589–600.

    Article  PubMed  CAS  Google Scholar 

  7. Lechner K, Obermeier HL. Cancer-related microangiopathic hemolytic anemia. Medicine. 2012;91:195–205.

    Article  PubMed  Google Scholar 

  8. Walker RW, Rosenblum MK, Kempin SJ, Christian MC. Carboplatin-associated thrombotic microangiopathic hemolytic anemia. Cancer. 1989;64(5):1017–20.

    Article  PubMed  CAS  Google Scholar 

  9. Fisher DC, Sherrill GB, Hussein A, Rubin P, Vredenburgh JJ, Elkordy M, Ross M, Petros W, Peters WP. Thrombotic microangiopathy as a complication of high-dose chemotherapy for breast cancer. Bone Marrow Transpl. 1996;18(1):193–8.

    CAS  Google Scholar 

  10. Dlott JS, Danielson CFM, Blue-Hnidy DE, McCarthy LJ. Drug induced thrombotic thrombocytopenic purpura/haemolytic uremic syndrome: a concise review. Ther Apher Dial. 2004;8(2):102–11.

    Article  PubMed  CAS  Google Scholar 

  11. Fields SM, Lindley CM. Thrombotic microangiopathy associated with chemotherapy: case report and review of the literature. DICP. 1989;23(7-8):582–8.

    PubMed  CAS  Google Scholar 

  12. Cantrell JE Jr, Phillips TM, Schein PS. Carcinoma-associated hemolytic-uremic syndrome: a complication of mitomycin C chemotherapy. J Clin Oncol. 1985;3(5):723–34.

    PubMed  Google Scholar 

  13. Snyder HW Jr, Mittelman A, Oral A, Messerschmidt GL, et al. Treatment of cancer chemotherapy-associated thrombotic thrombocytopenic purpura/hemolytic uremic syndrome by protein A immunoadsorption of plasma. Cancer. 1993;71(5):1882–92.

    Article  PubMed  Google Scholar 

  14. Onitilo AA, Engel JM, Clouse LH, Gerndt KM. Successful treatment of mitomycin-induced thrombotic thrombocytopenic purpura with rituximab. Vasc Interv Radiol. 2009;20(2):275–6.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, Vanderbilt University Medical Center, D-3100 Medical Center North, Nashville, TN, 37232-2358, USA

    Wade Iams & Kathyrn Eby Beckermann

  2. Department of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN, USA

    Anne T. Neff, Ingrid A. Mayer & Vandana Gupta Abramson

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  1. Wade Iams
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  2. Kathyrn Eby Beckermann
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  3. Anne T. Neff
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  4. Ingrid A. Mayer
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  5. Vandana Gupta Abramson
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Correspondence to Wade Iams.

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Iams, W., Beckermann, K.E., Neff, A.T. et al. Thrombotic microangiopathy during docetaxel, trastuzumab, and carboplatin chemotherapy for early-stage HER2+ breast cancer: a case report. Med Oncol 30, 568 (2013). https://doi.org/10.1007/s12032-013-0568-x

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  • DOI: https://doi.org/10.1007/s12032-013-0568-x

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