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Attenuated Salmonella typhimurium carrying the hepatocyte growth factor and keratinocyte growth factor genes repairs gastrointestinal mucosal damage caused by chemotherapy

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Abstract

Radiotherapy and chemotherapy are the main therapeutic approaches for patients with malignant tumours, especially advanced tumours. However, they can cause adverse effects, one of which is gastrointestinal mucosal damage, which can greatly affect patients’ quality of life. Until now, there have been no effective therapies to avoid or treat these adverse effects. In this study, we used attenuated Salmonella typhimurium (S. typhimurium) to deliver the hepatocyte growth factor (HGF) or keratinocyte growth factor (KGF) to murine gastrointestinal mucosa. We found that attenuated S. typhimurium carrying the HGF or KGF genes can effectively reduce the ratio of tumour to non-tumour carcass weight, repair damage to the gastrointestinal mucosal from chemotherapy, improve the immune response, and reduce the mortality rate of mice. Oral administration of attenuated S. typhimurium with HGF and KGF may be promising as a way of improving the quality of life of patients undergoing radiotherapy and chemotherapy.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (No. 81071839) and Capital Medical Development Foundation of China (2007–2040).

Conflict of interest

All authors have declared no conflict of interest.

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Authors and Affiliations

  1. Department of Oncology, The First Affiliated Hospital of General Hospital of Chinese PLA, Beijing, 100853, China

    Jun-zhong Sun

  2. Center of Medical Experiment, Lanzhou General Hospital of PLA, Lanzhou, 730050, Gansu, China

    Xiao-qin Ha

  3. No. 535 Hospital of Chinese People’s Liberation Army, Huaihua, 418008, Hunan, China

    Li-ming Zhang

  4. Department of Pathology, The First Affiliated Hospital of General Hospital of Chinese PLA, Beijing, 100853, China

    Hai-bin Wang & Hong-wei Wang

  5. Beijing Institute of Radiation Medicine (BIRM), Beijing, 100000, China

    Hai-feng Duan

Authors
  1. Jun-zhong Sun
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  2. Xiao-qin Ha
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  3. Li-ming Zhang
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  4. Hai-bin Wang
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  5. Hong-wei Wang
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  6. Hai-feng Duan
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Corresponding author

Correspondence to Hai-feng Duan.

Additional information

Jun-zhong Sun and Xiao-qin Ha contributed equally to this work.

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Sun, Jz., Ha, Xq., Zhang, Lm. et al. Attenuated Salmonella typhimurium carrying the hepatocyte growth factor and keratinocyte growth factor genes repairs gastrointestinal mucosal damage caused by chemotherapy. Med Oncol 30, 453 (2013). https://doi.org/10.1007/s12032-012-0453-z

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  • DOI: https://doi.org/10.1007/s12032-012-0453-z

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