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Genetic variations in transcription factor 7-like 2 (TCF7L2) gene: association of TCF7L2 rs12255372(G/T) or rs7903146(C/T) with breast cancer risk and clinico-pathological parameters

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Abstract

The purpose of the present study was to evaluate the association between TCF7L2 rs12255372(G/T) or rs7903146(C/T) polymorphism and breast cancer risk, and clinico-pathologic characteristics of the patients. Genotyping of these polymorphisms was performed on 387 breast cancer patients and 252 normal and healthy women who had no history of any malignancy using polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) method in a hospital-based Malaysian population. The allele (P = 0.033) frequency of rs7903146 (T) polymorphism was significantly higher in the cancer patients than normal individuals. No significant association was demonstrated between CT (ORadj = 1.386; 95% CI, 0.985–1.949) or TT (ORadj = 1.579; 95% CI, 0.869–2.870) genotype and breast cancer risk. However, women who were carriers of T allele (ORadj = 1.316; 95% CI, 1.022–1.695) or T allele genotype (ORadj = 1.419; 95% CI, 1.027–1.960) showed significant increased risk of breast cancer. Women who were GT heterozygotes (ORadj = 1.329; 95% CI, 0.948–1.862) or TT homozygotes (ORadj = 1.574; 95% CI, 0.829–2.987), and carriers of T allele genotype (ORadj = 1.365; 95% CI, 0.989–1.883) or T allele (ORadj = 1.284; 95% CI, 0.995–1.657) were not associated with breast cancer risk. The rs7903146(T) allele genotype was significantly associated with nodal involvement (P = 0.003) but rs12255372 (T) allele genotype was not associated with the clinico-pathologic characteristics. In conclusion, our findings suggest that rs7903146 (T) variant may elevate the risk of breast cancer, thus could be a potential candidate for breast cancer susceptibility. The variant may also increase the metastatic potential of the tumor.

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Acknowledgments

This study was financially supported by E-ScienceFund grant (02-02-10-SF0016) from Ministry of Science, Technology and Innovation, Malaysia.

Conflict of interest

The authors declare that they have no conflict of interest related to the publication of this manuscript.

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Authors and Affiliations

  1. School of Medicine and Health Sciences, Monash University Sunway Campus, Jalan Lagoon Selatan, 46150, Bandar Sunway, Selangor Darul Ehsan, Malaysia

    R. Naidu

  2. Department of Surgery, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia

    C. H. Yip & N. A. M. Taib

  3. University Malaya Medical Center, University of Malaya, 50603, Kuala Lumpur, Malaysia

    C. H. Yip & N. A. M. Taib

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  1. R. Naidu
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  2. C. H. Yip
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  3. N. A. M. Taib
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Correspondence to R. Naidu.

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Naidu, R., Yip, C.H. & Taib, N.A.M. Genetic variations in transcription factor 7-like 2 (TCF7L2) gene: association of TCF7L2 rs12255372(G/T) or rs7903146(C/T) with breast cancer risk and clinico-pathological parameters. Med Oncol 29, 411–417 (2012). https://doi.org/10.1007/s12032-011-9837-8

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  • DOI: https://doi.org/10.1007/s12032-011-9837-8

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