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Combination of narrow band imaging (NBI) and autofluorescence imaging (AFI) videobronchoscopy in endoscopic assessment of lung cancer extension

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Abstract

Both narrow band imaging (NBI) and autofluorescence imaging (AFI) are new techniques for the assessment of lung cancer. The major aim of this study was to investigate whether the combination of these two techniques improve sensitivity and specificity in the assessment of lung cancer extension. The study prospectively evaluated 118 patients with suspected lung cancer. All of the patients were examined using EVIS LUCERA SPECTRUM videobronchoscopy system. The narrow band imaging preceded autofluorescence imaging examination. In every patient, at least 1 but no more than 4 biopsies were taken from places visualized as pathologic, surrounding primary tumor, and at least 1 biopsy from places that appeared visually normal. Sensitivity, specificity, positive, and negative predictive value for autofluorescence imaging in the assessment of tumor extension were 89.2, 77.8, 87, and 81%, respectively. Sensitivity, specificity, positive, and negative predictive value for narrow band imaging were 90.4, 82.4, 91.8, and 79.7%, respectively. Corresponding values for combination of techniques were 93.7, 86.9, 94.5, and 85.1%. Combination of techniques significantly improves sensitivity (P = 0.034) with borderline effect on specificity (P = 0.056) of autofluorescence imaging. There was no significant improvement for sensitivity and specificity of NBI alone. The combination of techniques shows significantly better sensitivity and specificity in the assessment of lung cancer extension when compared to white light videobronchoscopy alone, but improvement is not so convincing when compared to the each technique alone.

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Acknowledgments

The study was partially conducted as a part of European Respiratory Society Fellowship grant no. 627, awarded to Dr B. Zaric. The study was partially supported by the grant of the Serbian Ministry of Science and Technology, grant number 175056.

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Authors and Affiliations

  1. Department for Interventional Pulmonology, Institute for Pulmonary Diseases of Vojvodina, Clinic for Pulmonary Oncology, Faculty of Medicine, University of Novi Sad, Serbia, Institutski put 4, 21204, Sremska Kamenica, Serbia

    Bojan Zaric, Branislav Perin, Svetlana Jovanovic, Milana Panjkovic, Biljana Zvezdin, Milorad Bijelovic & Milan Antonic

  2. Thoraxklinik, University of Heidelberg, Heidelberg, Germany

    Heinrich D. Becker, Felix FJ Herth & Ralf Eberhardt

  3. Clinical Center of Vojvodina, Clinic for Gastroenterohepatology, Novi Sad, Serbia

    Tihomir Orlic

  4. Institute for Cardiovascular Diseases of Vojvodina, Faculty of Medicine, University of Novi Sad, Sremska Kamenica, Serbia

    Aleksandra Jovelic

  5. Faculty of Medicine, University of Kragujevac, Kragujevac, Serbia

    Vladimir Jurisic

Authors
  1. Bojan Zaric
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  2. Branislav Perin
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  3. Heinrich D. Becker
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  4. Felix FJ Herth
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  5. Ralf Eberhardt
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  6. Svetlana Jovanovic
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  7. Tihomir Orlic
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  8. Milana Panjkovic
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  9. Biljana Zvezdin
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  10. Aleksandra Jovelic
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  11. Milorad Bijelovic
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  12. Vladimir Jurisic
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  13. Milan Antonic
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Corresponding author

Correspondence to Bojan Zaric.

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Zaric, B., Perin, B., Becker, H.D. et al. Combination of narrow band imaging (NBI) and autofluorescence imaging (AFI) videobronchoscopy in endoscopic assessment of lung cancer extension. Med Oncol 29, 1638–1642 (2012). https://doi.org/10.1007/s12032-011-0038-2

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  • DOI: https://doi.org/10.1007/s12032-011-0038-2

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