Medical Oncology

, Volume 28, Issue 4, pp 941–944 | Cite as

Malignant transformation of foveolar hyperplastic polyp of the stomach: a histopathological study

  • Tadashi TeradaEmail author
Original Paper


The author investigated histopathology of malignant changes of gastric foveolar hyperplastic polyps (GFHP). A total of 497 GFHP from 412 patients were retrospectively examined. Malignant changes were present in 11 GHP (2.2%). They were focal malignancies and well-differentiated adenocarcinoma without apparent invasion. In all the 11 GFHP, dysplastic glands were present in the vicinity of carcinomatous foci. Focal intestinal metaplasia was recognized in one case and was absent in the remaining 10 GFHP. Focal dysplastic glands were recognized in 51 GFHP (10%). Of these, four GFHP were associated with focal intestinal metaplasia, but the remaining 47 GFHP were not associated with intestinal metaplasia. Intestinal metaplasia alone was recognized in 23 GFHP (5%). Immunohistochemically, all carcinomatous foci within the 11 GFHP with malignant transformation showed positive p53 expression and high Ki-67 labeling. Of the 51 GFHP with dysplasia, 42 GFHP were positive for p53 protein, and the remaining 9 GFHP were negative for p53 protein. The dysplastic lesions of the 51 GFHP showed relatively high Ki-67 index. Intestinal metaplasia within GFHP was negative for p53 protein and showed low Ki-67 labeling. These results suggest that malignant transformation of GFHP may occur in 2.2% of cases, and that malignant changes develop via hyperplasia–dysplasia–carcinoma sequence in GFHP. Intestinal metaplasia within GFHP was not associated with carcinogenesis of GFHP.


Gastric hyperplastic polyp Malignant transformation Histopathology 



Conflict of interest statement

The author has no conflict of interest.


  1. 1.
    Daibo M, Itabashi M, Hirota T. Malignant transformation of gastric hyperplastic polyp. Am J Gastroenterol. 1987;82:1016–25.PubMedGoogle Scholar
  2. 2.
    Oriowska J, Jarosz D, Pachlewski J, Butruk E. Malignant transformation of benign epithelial gastric polyps. Am J Gastroenterol. 1995;90:2152–9.Google Scholar
  3. 3.
    Zea-Iriarte WL, Sekine I, Itsuno M, Makiyama K, Naito S, Nakayama T, et al. Carcinoma in gastric hyperplastic polyps: a phenotypic study. Dig Dis Sci. 1996;41:377–86.PubMedCrossRefGoogle Scholar
  4. 4.
    Abraham SC, Singh VK, Yardley JH, Wu TT. Hyperplastic polyps of the stomach: association with histologic patterns of gastritis and gastric atrophy. Am J Surg Pathol. 2001;25:500–7.PubMedCrossRefGoogle Scholar
  5. 5.
    Fenoglio-Preiser C, Carneiro F, Correa P, Guilford P, Lambert R, Megraud F, et al. Gastric carcinoma. In: Hamilton SR, Aaltonen LA, editors. WHO Classification of tumours. Pathology and genetics, tumours of the digestive system. Lyon: IARC Press; 2000. p. 39–52.Google Scholar
  6. 6.
    Terada T, Kawaguchi M. Primary clear cell adenocarcinoma of the peritoneum. Tohoku J Exp Med. 2005;206:271–5.PubMedCrossRefGoogle Scholar
  7. 7.
    Terada T, Kawaguchi M, Furukawa K, Sekido Y, Osamura Y. Minute mixed ductal-endocrine carcinoma of the pancreas with predominant intraductal growth. Pathol Int. 2002;52:740–6.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of PathologyShizuoka City Shimizu HospitalShizuokaJapan

Personalised recommendations