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Medical Oncology

, Volume 27, Issue 3, pp 690–696 | Cite as

Intestinal permeability, vitamin A absorption, alpha-tocopherol, and neopterin in patients with rectal carcinoma treated with chemoradiation

  • Josef Dvořák
  • Bohuslav MelicharEmail author
  • Radomír Hyšpler
  • Lenka Krčmová
  • Lubor Urbánek
  • Hana Kalábová
  • Markéta Kašparová
  • Dagmar Solichová
Original Paper

Abstract

Although gastrointestinal toxicity is one of the most common side effects of anticancer therapy, the diagnosis and assessment of this toxicity still depend mostly on anamnestic data. Measurement of intestinal permeability is one of potential methods of non-invasive laboratory evaluation of gastrointestinal toxicity. The aim of the present study was to investigate intestinal permeability, vitamin A absorption, serum alpha-tocopherol, and urinary neopterin in patients with rectal carcinoma treated with chemoradiation. We have studied intestinal permeability, vitamin A absorption, serum alpha-tocopherol, and urinary neopterin in 17 patients with rectal carcinoma treated with chemoradiation. Urinary lactulose, mannitol, and xylose were measured by capillary gas chromatography, and serum alpha-tocopherol, retinol, retinyl esters, and urinary neopterin were determined by high-performance liquid chromatography. Lactulose/mannitol ratio was increased 5 and 6 weeks after the start of the treatment. Serum alpha-tocopherol was decreased significantly throughout the course of treatment, but no significant changes were observed in postprandial serum concentrations of retinyl esters or in the concentrations of urinary neopterin. A correlation was observed between baseline parameters of intestinal permeability and urinary neopterin. The measurement of intestinal permeability using the lactulose/mannitol test may represent a sensitive tool in the detection of changes associated with chemoradiation in patients with rectal carcinoma. The therapy is also associated with a decrease of alpha-tocopherol.

Keywords

Alpha-tocopherol 5-fluorouracil Intestinal permeability Neopterin Radiation Rectal carcinoma Retinyl esters 

Notes

Acknowledgments

This study was supported by the grant of the Internal Grant Agency of the Czech Republic NR9096-4 and Research Project MZO 00179906.

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Copyright information

© Humana Press Inc. 2009

Authors and Affiliations

  • Josef Dvořák
    • 1
  • Bohuslav Melichar
    • 1
    • 4
    Email author
  • Radomír Hyšpler
    • 2
  • Lenka Krčmová
    • 2
    • 3
  • Lubor Urbánek
    • 2
    • 3
  • Hana Kalábová
    • 1
  • Markéta Kašparová
    • 2
    • 3
  • Dagmar Solichová
    • 2
  1. 1.Department of Oncology & RadiotherapyCharles University Medical School and Teaching HospitalHradec KrálovéCzech Republic
  2. 2.Department of Gerontology & Metabolic CareCharles University Medical School and Teaching HospitalHradec KrálovéCzech Republic
  3. 3.Department of Analytical ChemistryCharles University School of PharmacyHradec KrálovéCzech Republic
  4. 4.Department of OncologyPalacký University Medical School and Teaching HospitalOlomoucCzech Republic

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