Down-regulation of miR-31 expression in gastric cancer tissues and its clinical significance
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MicroRNAs (miRNAs) are non-coding RNAs that regulate the expression of target mRNAs. Altered expression of specific miRNAs in several tumor types has been reported. However, the expression levels of miR-31 in gastric cancers are unclear. The objective of the present study was to compare the expression profile of miR-31 between gastric cancer tissues and non-tumor tissues. Real-time quantitative reverse transcription-polymerase chain reaction technology was used to detect the levels of miR-31 expression. The expression levels of miR-31 in gastric cancer tissues were significantly lower than those in non-tumor tissues. This new information may help to clarify the molecular mechanisms involved in gastric carcinogenesis and to indicate that miR-31 may be a novel diagnostic biomarker of gastric cancer.
KeywordsMicroRNA-31 Gastric cancer Gene expression Gene diagnosis
This work was supported by Scientific Research Fund of Zhejiang Provincial Education Department (No. 20070965), Student Innovation and Open Laboratory Program of Ningbo University (No. Cxxkf 2008-067), Ningbo Natural Science Foundation (No. 2009A610134), Zhejiang Province Research Project (No. 2008C33020, and No. 2008F70052), Zhejiang Natural Sciences Foundation (No. Y207240 and No. Y207244), National Natural Science Foundation of China (No. 30872420), and K. C. Wong Magna Fund in Ningbo University.
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