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Medical Oncology

, Volume 27, Issue 2, pp 286–290 | Cite as

T-cell large granular lymphocytic (T-LGL) leukemia: a single institution experience

  • Aleksandra Sretenovic
  • Darko AnticEmail author
  • Snezana Jankovic
  • Mirjana Gotic
  • Maja Perunicic-Jovanovic
  • Ljubomir Jakovic
  • Biljana Mihaljevic
Original Paper

Abstract

Background T-cell large granular lymphocytic (T-LGL) leukemia is a rare lymphoproliferative disease which usually affects elderly people. The clinical course of T-LGL leukemia is generally indolent, with lymphocytosis and splenomegaly in 20–50% patients, hepatomegaly in 5–20% of patients, and less commonly, lymphadenopathy. T-LGL leukemia is associated with immunological abnormalities: rheumatoid factor with or without rheumatoid arthritis (RA), Coombs positive hemolytic anemia, idiopathic thrombocytopenic purpura (ITP), pure red cell aplasia (PRCA), positive anti-nuclear antibodies (ANA), anti-neutrophil cytoplasmic antibodies (ANCA), hypogammaglobulinemia, and polyclonal hypergammaglobulinemia. Aim To compare clinical and laboratory features of T-LGL leukemia patients and their responses to different chemotherapy regimens. Methods Six patients (3 males and 3 females) with T-LGL leukemia were analyzed. The diagnosis was based on accepted morphologic criteria, immunophenotype, and polymerase chain reaction (PCR) detection of T-cell receptor (TCR) gene rearrangements. Results All patients exhibited lymphocytosis, mainly with unusual morphologies, splenomegaly, and elevated serum lactate dehydrogenase (LDH). Three patients were treated with a Fludarabine–Cyclophosphamide (FC) combination as initial therapy while three patients received CHOP. Two patients received more than one treatment regimen. One patient died due to T-LGL leukemia in first year after diagnosis, one patient died 4 years after diagnosis, two patients interrupted their treatment, and two patients are still alive. Conclusions Further prospective studies are needed for establishing a gold standard therapy for T-LGL leukemia.

Keywords

T-cell leukemia Large granular lymphocytic leukemia T-LGL leukemia Clinical data Chemotherapy 

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Copyright information

© Humana Press Inc. 2009

Authors and Affiliations

  • Aleksandra Sretenovic
    • 1
  • Darko Antic
    • 1
    Email author
  • Snezana Jankovic
    • 1
  • Mirjana Gotic
    • 1
  • Maja Perunicic-Jovanovic
    • 1
  • Ljubomir Jakovic
    • 1
  • Biljana Mihaljevic
    • 1
  1. 1.Institute of HematologyClinical Center SerbiaBelgradeSerbia

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