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Frequency of FLT3 mutations in childhood acute lymphoblastic leukemia

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FLT3 mutations are occasionally observed in acute lymphoblastic leukemia (ALL). These most frequently manifest as internal tandem duplications (ITD) and activation loop (AL) mutations. This study investigated the incidence of FLT3 mutations in 86 pediatric patients diagnosed with ALL and the co-presence of common RAS mutations. A 2.3% (2/86) FLT3/AL mutation rate in terms of total ALL cases and a 22% (2/9) incidence in hyperdiploid cases was observed. This is in accordance to previous studies indicating a higher incidence in the patient subgroup associated with hyperdiploidy.

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The authors gratefully acknowledge Dr. Alexandra Perry for assistance with editing, Eleni Koniari for technical help, and George Lambrou and Dr. Spiros Vlachopoulos for technical advice.

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Correspondence to M. Braoudaki.

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Braoudaki, M., Karpusas, M., Katsibardi, K. et al. Frequency of FLT3 mutations in childhood acute lymphoblastic leukemia. Med Oncol 26, 460–462 (2009).

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