Skip to main content

Advertisement

SpringerLink
Log in

Acute lymphoblastic leukemia during gestation

  • Original Paper
  • Published:
Medical Oncology Aims and scope Submit manuscript

Abstract

The management of the common acute lymphoblastic leukemia in pregnancy has been controversial, but currently aggressive chemotherapy is the practice trend worldwide. We treated a young pregnant patient with aggressive regimen and we achieved full remission of the disease without affecting the fetus adversely. The management options are discussed thoroughly.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Lichtman MA, Liesveld JL. Acute myelogenous leukemia. In: Beutler E, Lichtman MA, Coller BS, Kipps TJ, Seligsohn U, editors. Williams hematology, 6th ed. New York: McGraw-Hill; 2001, p. 1047.

    Google Scholar 

  2. Buekers TE, Lallas TA. Chemotherapy in pregnancy. Obstet Gynecol Clin North Am. 1998;25:323–9.

    Article  PubMed  CAS  Google Scholar 

  3. Iseminger KA, Lewis MA. Ethical challenges in treating mother and fetus when cancer complicates pregnancy. Obstet Gynecol Clin North Am. 1998;25:273–85.

    Article  PubMed  CAS  Google Scholar 

  4. Moricke A, Zimmermann M, Reiter A, Gadner H, Odenwald E, Harbott J, Ludwig WD, Riehm H, Schrappe M. Prognostic impact of age in children and adolescents with acute lymphoblastic leukemia: data from the trials ALL-BFM 86, 90, and 95. Klin Padiatr. 2005;217(6):310–20.

    Article  PubMed  CAS  Google Scholar 

  5. Cardonick E, Iacobucci A. Use of chemotherapy during human pregnancy. Lancet Oncol. 2005;5:283–91.

    Article  CAS  Google Scholar 

  6. Briggs GC, Freeman RK, Yaffee SJ. A reference guide to fetal and neonatal risk: drugs in pregnancy and lactation, 5th ed. Philadelphia: Williams and Wilkins; 1998.

    Google Scholar 

  7. Terek MC, Ozkinay E, Zekioglu O, Erhan Y, Cagirgan S, Pehlivan M, Mgoyi L. Acute leukaemia in pregnancy with ovarian metastasis: a case report and review of the literature. Int J Gynecol Cancer. 2003;13:904–8.

    Article  PubMed  CAS  Google Scholar 

  8. Larson RA, Dodge RK, Linker CA, Stone RM, Powell BL, Lee EJ, et al. A randomized controlled trial of filgrastim during remission, induction and consolidation chemotherapy for adults with acute lymphoblastic leukemia: CALGB study 9111. Blood. 1998;92:1556–64.

    PubMed  CAS  Google Scholar 

  9. Aviles A, Neri N. Hematological malignancies and pregnancy: a final report of 84 children who received chemotherapy in utero. Clin Lymphoma. 2001;2:173–7.

    Article  PubMed  CAS  Google Scholar 

  10. Peleg D, Ben-Ami M. Lymphoma and leukemia complicating pregnancy. Obstet Gynecol Clin North Am. 1998;25:365–81.

    Article  PubMed  CAS  Google Scholar 

  11. Chelghoum Y, Vey N, Raffoux E, Huguet F, Pigneux A, Witz B, Pautas C, Botton S, Guyotat D, Lioure B, Fegueux N, Garban F, Saad H, Thomas X. Acute leukemia during pregnancy, a report on 37 patients and a review of the literature. Cancer 2005;104(1):110–7.

    Article  PubMed  Google Scholar 

  12. Dilek I, Topcu N, Demir C, Bay A, Uzun K, Gul A, Faik Oner A, Ugras S. Hematological malignancy and pregnancy: a single-institution experience of 21 cases. Clin Lab Haematol. 2006;28:170–6.

    Article  PubMed  CAS  Google Scholar 

  13. Lishner M, Koren G. Cancer chemotherapy during pregnancy. Consortium of cancer in pregnancy evidence. Can Fam Physician. 2001;47:41–42.

    PubMed  CAS  Google Scholar 

  14. Hansen WF, Fretz P, Hunter SK, Yankowitz J. Leukemia in pregnancy and fetal response to multiagent chemotherapy. Obstet Gynecol. 2001;97(5 Pt 2):809–12.

    Article  PubMed  CAS  Google Scholar 

  15. Ali R, Ozkalemkas F, Ozcelik T, et al. Maternal and fetal outcomes in pregnancy complicated with acute leukaemia: a single institutional experience with 10 pregnancies ay 16 years. Leuk Res. 2003;27:381–5.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. “Alexandra” General Hospital, V. Sofias and Lourou 1, 11528, Athens, Greece

    Charis Matsouka, Spyridon Marinopoulos, Despina Barbaroussi & Aris Antsaklis

  2. Department of Haematology, Athens, Greece

    Charis Matsouka & Despina Barbaroussi

  3. 1st Department of Obstetrics & Gynaecology, University of Athens, Athens, Greece

    Spyridon Marinopoulos & Aris Antsaklis

  4. 95 Agias Barbaras Street, 152 31, Halandri, Athens, Greece

    Spyridon Marinopoulos

Authors
  1. Charis Matsouka
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Spyridon Marinopoulos
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Despina Barbaroussi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Aris Antsaklis
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Spyridon Marinopoulos.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Matsouka, C., Marinopoulos, S., Barbaroussi, D. et al. Acute lymphoblastic leukemia during gestation. Med Oncol 25, 190–193 (2008). https://doi.org/10.1007/s12032-007-9024-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12032-007-9024-0

Keywords

Search

Navigation