Skip to main content
SpringerLink
Log in

Immunophenotypic profile and clinical characteristics in patients with advanced stage mantle cell lymphoma

  • Original Paper
  • Published:
Medical Oncology Aims and scope Submit manuscript

Abstract

The objective of this study was to evaluate immunophenotypic profile along with clinical follow-up in patients with advanced stage mantle cell lymphoma (MCL), and their possible influence on overall survival (OS). Bone marrow (BM) cell and/or peripheral blood mononuclear cell flow cytometric analyses of the following antigens were performed: HLA–DR, CD19, CD20, CD22, CD23, CD25, CD10, SmIg, kappa, lambda, CD79b, CD38, FMC7, CD3, CD2, and CD5. There were 14 patients in IV CS, and 26 patients in CS V. All patients were treated with CHOP. Immunological markers showed a typical phenotype (CD5+ CD23-, Cyclin D1) in all cases. Pathohystological type of BM infiltration was predominantly diffuse (72.5%), and in remainder of patients, nodular. Comparison of patients with leukemic phase of MCL with CSIV (BM), has shown significantly higher expression of CD19, CD20, and CD23, followed by permanently negative expression of CD23. Patients with blastic variant of MCL had higher expression of CD23, compared to typical MCL (P < 0.001). Median OS was 20 months, and there were no significant OS-differences between CS IV and leukemic phase patients. Survival analyses showed that negative prognostic influence had high IPI (P < 0.01), presence of extranodal localization (P < 0.01), and diffuse type of BM involvement (P < 0.01). Using Cox regression according to OS, IPI had independent prognostic value (P < 0.001). Our results demonstrated that in the advanced MCL patients the most powerful prognostic factor was IPI, while extranodal localization and type of BM infiltration were of a limited value.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Harris NL, et al. A revised European–American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 1994;84:1361–92.

    PubMed  CAS  Google Scholar 

  2. Raffeld M, Jaffe ES. Bcl–1, t (11; 14), and mantle cell–derived lymphomas. Blood 1991;78:259–63.

    PubMed  CAS  Google Scholar 

  3. Cordell JL, et al. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti–alkaline phosphatese (APAAP–complexes). J Histoch Cytochem 1984;32:219–29.

    CAS  Google Scholar 

  4. Wohlschlaeger CH, Lange HM, Feller AC. Aberrant immunophenotypes of mantle cell lymphomas. Leuk Lymphoma 2003;44:269–73.

    Article  PubMed  Google Scholar 

  5. Matutes E, et al. The leukemic presentation of mantle–cell lymphoma: disease features and prognostic factors in 58 patients. Leuk Lymphoma 2004;45:2007–15.

    Article  PubMed  CAS  Google Scholar 

  6. Weisenburger DD, Armitage JO. Mantle cell lymphoma; an entity comes of age. Blood 1996;87:4483–94.

    PubMed  CAS  Google Scholar 

  7. Donfrid–Todorovic M, et al. Monocytoid B cell lymphoma associated with antibodies to myelin–associated glycoprotein and sulphated glucuronyl paragloboside. Acta Haematol 2001;106:130–2.

    Article  PubMed  CAS  Google Scholar 

  8. Rodig SJ, et al. Mantle cell lymphoma arising within primary nodal marginal zone lymphoma: a unique presentation of two uncommon B–cell lymphoproliferative disorders. Cancer Genet Cytogenet 2006;171:44–51.

    Article  PubMed  CAS  Google Scholar 

  9. Pittaluga S, et al. Prognostic significance of bone marrow trephine biopsy and peripheral blood smears in 55 patients with mantle cell lymphoma. Leuk Lymphoma 1996;21:115–25.

    PubMed  CAS  Google Scholar 

  10. Samaha H, et al. Mantle cell lymphoma: a retrospective study of 121 cases. Leukemia 1998;12:1281–7.

    Article  PubMed  CAS  Google Scholar 

  11. Bosch F, et al. Mantle cell lymphoma: presenting features, response to therapy, and prognostic factors. Cancer 1998;82:567–75.

    Article  PubMed  CAS  Google Scholar 

  12. Cohen PL, Kurtin PJ, Donovan KA, Hanson CA. Bone marrow and peripheral blood involvement in mantle cell lymphoma. Br J Haematol 1998;101:302–10.

    Article  PubMed  CAS  Google Scholar 

  13. Chuang SS, et al. Mantle cell lymphoma in Taiwan: clinicopathological and molecular study of 21 cases including one cyclin D1–negative tumor expressing cyclin D2. Pathol Int 2006;56:440–8.

    Article  PubMed  CAS  Google Scholar 

  14. Zhang L, Kern WF, Yu Z, Mulvihill JJ. Li. Cryptic and complex chromosomal rearrangements and the deletion of TP53. Cancer Genet Cytogenet 2006;169:169–73.

    Article  PubMed  CAS  Google Scholar 

  15. Yin CC, et al. Sequence analysis proves clonal identity in five patients with typical and blastoid mantle cell lymphoma. Mod Pathol 2007;20:1–7.

    Article  PubMed  CAS  Google Scholar 

  16. Parrens M, et al. Blastoid and common variants of mantle cell lymphoma exhibit distinct immunophenotypic and interphase FISH features. Histopathology 2006;48:353–62.

    Article  PubMed  CAS  Google Scholar 

  17. Sarfati M, Fournier S, Wu CY, Delespesse G. Expression, regulation and function of human Fc epsilon RII (CD23) antigen. Immunol Res 1992;11:260–72.

    Article  PubMed  CAS  Google Scholar 

  18. Prinz JC, Baur X, Mazur G, Rieber EP. Allergen–directed expression of Fc receptors for IgE (CD23) on human T lymphocytes is modulated by interleukin 4 and interferon–gamma. Eur J Immuno 1990;20:1259–64.

    Article  CAS  Google Scholar 

  19. Reljic R, Cosentino G, Gould HJ. Function of CD23 in the response of human B cells to antigen. Eur J Immunol 1997;27:572–5.

    Article  PubMed  CAS  Google Scholar 

  20. Lai R, et al. Immunoglobulin VH somatic hypermutation in mantle cell lymphoma: mutated. Mod Pathol 2006;19:1498–05.

    PubMed  CAS  Google Scholar 

  21. Salar A, et al. Gastrointestinal involvement in mantle cell lymphoma: a prospective clinic, endoscopic, and pathologic study. Am J Surg Pathol 2006;30:1274–80.

    Article  PubMed  Google Scholar 

  22. Nickenig C, et al. German Low–Grade Lymphoma Study Group. Combined cyclophosphamide, vincristine, doxorubicin, and prednisone (CHOP) improves response rates but not survival and has lower hematologic toxicity compared with combined mitoxantrone, chlorambucil, and prednisone (MCP) in follicular and mantle cell lymphomas: results of a prospective randomized trial of the German Low–Grade Lymphoma Study Group. Cancer 2006;107:1014–22.

    Article  PubMed  CAS  Google Scholar 

  23. Ritchie DS, et al. The hyper–CVAD–rituximab chemotherapy programme followed by high–dose busulfan, melphalan and autologous stem cell transplantation produces excellent event–free survival in patients with previously untreated mantle cell lymphoma. Ann Hematol 2007;86:101–5.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Hematology, Clinical Center of Serbia, Belgrade, Serbia

    M. Todorovic, N. Kraguljac, B. Mihaljevic, A. Bogdanovic, I. Elezovic, D. Boskovic & M. Colovic

  2. Department of Biology, Charles Smith College of Science, Florida Atlantic University, Boca Raton, FL, USA

    M. Pavlovic

  3. Department of Experimental Hematology, Institute for Medical Research, Belgrade University, Belgrade, Serbia

    B. Balint

Authors
  1. M. Todorovic
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Pavlovic
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. Balint
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. Kraguljac
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. B. Mihaljevic
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. Bogdanovic
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. I. Elezovic
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. D. Boskovic
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. M. Colovic
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. Todorovic.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Todorovic, M., Pavlovic, M., Balint, B. et al. Immunophenotypic profile and clinical characteristics in patients with advanced stage mantle cell lymphoma. Med Oncol 24, 413–418 (2007). https://doi.org/10.1007/s12032-007-0029-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12032-007-0029-5

Keywords

Search

Navigation