Abstract
This article discusses a rare case of coexistent meningiomas and Primary familial brain calcification (PFBC). PFBC is a neurodegenerative disease characterized by brain calcifications and a variety of neuropsychiatric symptoms and signs, with pathogenic variants in specific genes. The study explores the potential link between PFBC and meningiomas, highlighting shared features like intralesional calcifications and common genes such as MEA6. The article also revisits PFBC patients developing other brain tumors, particularly gliomas, emphasizing the intersection of oncogenes like PDGFB and PDGFRB in both calcifications and tumor progression. In recent investigations, attention has extended beyond brain tumors to breast cancer metastasis, unveiling a noteworthy connection. These findings suggest a broader connection between brain calcifications and tumors, encouraging a reevaluation of therapeutic approaches for PFBC.
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No datasets were generated or analysed during the current study.
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Funding
This work was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (311,664/2020-2) and Programa Institucional de Bolsas de Iniciação Científica (PIBIC) from Universidade Federal de Pernambuco (UFPE).
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E.S.G. and J.R.M.O. contributed to the study conception, data collection, and analysis. Manuscript was written by E.S.G. and reviewed by J.R.M.O. All authors commented on previous versions of the manuscript and approved the final manuscript.
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de Godoy, E.S., de Oliveira, J.R.M. Exploring the Biological Overlapping Between Brain Calcifications and Tumorgenesis. J Mol Neurosci 74, 54 (2024). https://doi.org/10.1007/s12031-024-02230-6
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DOI: https://doi.org/10.1007/s12031-024-02230-6