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Expression of Linear and Circular lncRNAs in Alzheimer’s Disease

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Abstract

Alzheimer’s disease is a neurodegenerative disorder of the elderly described by progressive cognitive debility. Recent studies have displayed the significance of linear and circular long non-coding RNAs (lncRNAs) in the pathobiology of Alzheimer’s disease. These studies have reported the downregulation of MALAT1, while the upregulation of NEAT1, RP11-543N12.1, SOX21-AS1, BDNF-AS, BACE1-AS, ANRIL, XIST, and some other linear lncRNAs in clinical samples are obtained from these patients or animal models of Alzheimer’s disease. A number of circRNAs such as ciRS-7, ciRS-7, circNF1-419, circHDAC9, circ_0000950,and circAβ-a have been shown to partake in the pathogenesis of this disorder. In the present manuscript, we provide a review of the impact of linear and circular lncRNAs in the pathobiology of Alzheimer’s disease and their potential application as markers for this neurodegenerative condition.

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The analyzed data sets generated during the study are available from the corresponding authors on reasonable request.

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Acknowledgements

This study was financially supported by Shahid Beheshti University of Medical Sciences.

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Authors and Affiliations

  1. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Soudeh Ghafouri-Fard

  2. Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

    Mohammadreza Safari

  3. Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mohammad Taheri

  4. Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mohammad Samadian

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  1. Soudeh Ghafouri-Fard
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  2. Mohammadreza Safari
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  3. Mohammad Taheri
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  4. Mohammad Samadian
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Contributions

SGF wrote the draft and revised it. MT and MS collected the data and designed the tables and figures. All the authors contributed equally and read the submission.

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Correspondence to Mohammad Taheri or Mohammad Samadian.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent forms were obtained from all study participants. The study protocol was approved by the ethical committee of Shahid Beheshti University of Medical Sciences. All methods were performed in accordance with the relevant guidelines and regulations.

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Ghafouri-Fard, S., Safari, M., Taheri, M. et al. Expression of Linear and Circular lncRNAs in Alzheimer’s Disease. J Mol Neurosci 72, 187–200 (2022). https://doi.org/10.1007/s12031-021-01900-z

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