Rodent Models of Vascular Cognitive Impairment

Tuo, Qing-zhang; Zou, Jin-jun; Lei, Peng

doi:10.1007/s12031-020-01733-2

Published: 27 October 2020

Rodent Models of Vascular Cognitive Impairment

Journal of Molecular Neuroscience volume 71, pages 1–12 (2021)Cite this article

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Abstract

Vascular cognitive impairment (VCI) refers to the entire spectrum of vascular brain pathologies that contribute to cognitive deficits, ranging from subjective cognitive decline to dementia. The main pathologies in VCI are infarcts and white matter hyperintensities due to ischemia. VCI rodent models can be divided into surgical models (e.g., MCAO, BCAO, BCAS, 2-VO, 4-VO) and genetic models (e.g., SHR/SP, T2DM, CAA, CADASIL) based on construction methods. However, no single model can fully recapitulate the pathogenesis of VCI, and choosing the appropriate model for different research purposes would be of crucial importance. Here, we have summarized the commonly used rodent VCI models and discussed their advantages and limitations to provide a necessary reference for selecting suitable animal models to investigate the molecular pathways involved in VCI and develop therapeutic interventions.

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Funding

This work was supported by the National Key Research and Development Project of China (2018YFC1312300), the National Natural Science Foundation of China (81722016, 81801182), the China Postdoctoral Science Foundation (2017M623041, 2019T120848), and the Post Doctor Research Project, West China Hospital, Sichuan University (2018HXBH044).

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Department of Neurology and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China
Qing-zhang Tuo, Jin-jun Zou & Peng Lei

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Qing-zhang Tuo
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Jin-jun Zou
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Peng Lei
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Correspondence to Peng Lei.

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Tuo, Qz., Zou, Jj. & Lei, P. Rodent Models of Vascular Cognitive Impairment. J Mol Neurosci 71, 1–12 (2021). https://doi.org/10.1007/s12031-020-01733-2

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Received: 24 September 2020
Accepted: 12 October 2020
Published: 27 October 2020
Issue Date: May 2021
DOI: https://doi.org/10.1007/s12031-020-01733-2

Keywords

Vascular cognitive impairment
Dementia
Alzheimer’s disease
Chronic global hypoperfusion
MCAO
SHR/SP